{"id":"W3215727946","doi":"10.1038/s41589-021-00900-9","title":"Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase","year":2021,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Cancer Institute; National Science Foundation; U.S. Department of Health and Human Services; Government of Canada; University of Toronto","keywords":"ATP synthase; Leukemia; Chemistry; Cell biology; Biology; Biochemistry; Computational biology; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001101822,0.0002052398,0.0003118936,0.00002946152,0.00005479042,0.000009943446,0.0002044548,0.001099468,0.0001023805],"category_scores_gemma":[0.0005836152,0.0001840274,0.0001979205,0.0001972569,0.0002759223,0.00000571153,0.0002849798,0.000507994,0.00001490199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005015159,"about_ca_system_score_gemma":0.0002458022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001444451,"about_ca_topic_score_gemma":0.000001886389,"domain_scores_codex":[0.9985145,0.00009980667,0.000298998,0.0005509714,0.0001390292,0.0003967186],"domain_scores_gemma":[0.9990917,0.00007277692,0.00009021942,0.0004095725,0.0002388527,0.00009684328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001690985,0.00009043863,0.0004899956,0.00004013121,0.00006620133,0.00002932775,0.00001791352,0.000002015028,0.9938315,0.0007035778,0.003749583,0.0008102408],"study_design_scores_gemma":[0.0005498936,0.0001073665,0.00005804537,0.00002300031,0.0000132473,0.0000214263,0.00005101331,0.000009629208,0.9393795,0.001219592,0.05837939,0.0001879615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908264,0.005452955,0.0005905141,0.000574296,0.0001305356,0.0000991316,0.0001488788,0.00001862677,0.002158646],"genre_scores_gemma":[0.9936848,0.0005520841,0.002774292,0.001070502,0.0003976378,0.00001738454,0.001343227,0.00002363207,0.0001363833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05462981,"threshold_uncertainty_score":0.8480102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01218367360170804,"score_gpt":0.3074687785728009,"score_spread":0.2952851049710928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}