{"id":"W3215776049","doi":"10.1038/s41467-021-27306-4","title":"Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institute for Research in Immunology and Cancer; McGill University Health Centre; Sinai Health System; HEC Montréal; Lunenfeld-Tanenbaum Research Institute; Université Laval; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Starvation; Nucleus; Cell biology; Apoptosis; Proteasome; Autophagy; Amino acid; Programmed cell death; Cell nucleus; Biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001128361,0.0002003712,0.000211865,0.0001493355,0.0001829009,0.000320001,0.0001439186,0.0002027591,0.0007793312],"category_scores_gemma":[0.0001129272,0.0001014696,0.0001805843,0.00008298674,0.0002620344,0.0002934352,0.0002795497,0.0003173133,0.0003666338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003064163,"about_ca_system_score_gemma":0.0001939641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002467068,"about_ca_topic_score_gemma":0.0005385618,"domain_scores_codex":[0.9999276,0.00001122505,0.00000785208,0.00001555755,0.0000210884,0.00001656395],"domain_scores_gemma":[0.9998795,0.00001242861,0.00004182675,0.00001489312,0.00001464875,0.00003673061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001287456,0.000005829725,0.0004453899,0.00002046497,0.000003666855,0.00008535037,0.000009162693,0.00004281539,0.9983268,0.0001349845,0.00002841434,0.0007683511],"study_design_scores_gemma":[0.000006493487,0.0001008485,0.01030141,0.000006142958,0.000006078152,0.0003442962,0.00003078524,0.0005242024,0.9870724,0.0001641567,0.001439699,0.00000348057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880526,0.00369512,0.006578708,0.0001540459,0.00002870722,0.00001181781,0.0002179325,0.0001353779,0.001125725],"genre_scores_gemma":[0.9962677,0.0007940165,0.001604769,0.00003395687,0.000007665565,0.000009155016,0.0002150524,0.00001268945,0.001055009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007793312,"threshold_uncertainty_score":0.002607107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02895993479886214,"score_gpt":0.3009884095399641,"score_spread":0.2720284747411019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}