{"id":"W3215800873","doi":"10.1126/science.abl6251","title":"Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain","year":2022,"lang":"en","type":"article","venue":"Science","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of General Medical Sciences; Centers for Disease Control and Prevention","keywords":"Neutralization; Antibody; Virology; Immune escape; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Receptor; Coronavirus disease 2019 (COVID-19); Neutralizing antibody; Glycan; 2019-20 coronavirus outbreak; Mutation; Immunology; Gene; Genetics; Glycoprotein; Medicine; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001432798,0.0001895053,0.0001486671,0.00008679148,0.0001458293,0.0002342365,0.0002850055,0.0003162475,0.0009895571],"category_scores_gemma":[0.0001568143,0.00008544161,0.0001788495,0.00005650526,0.0002315685,0.0002042362,0.0002190925,0.0004088152,0.0002584161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002062806,"about_ca_system_score_gemma":0.0002254415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00039984,"about_ca_topic_score_gemma":0.0004081124,"domain_scores_codex":[0.9999138,0.00001767695,0.000005055931,0.00001275019,0.0000255876,0.00002512542],"domain_scores_gemma":[0.9999268,0.00001135739,0.00002140877,0.000008346015,0.00001291226,0.0000191678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001361006,0.00005332765,0.002588031,0.00002706553,0.00001171452,0.0003793847,0.0000268149,0.0005037836,0.9939981,0.0008155424,0.00008227685,0.001377808],"study_design_scores_gemma":[0.0001801939,0.001954846,0.08013,0.00003137135,0.00007121239,0.006380906,0.0002832945,0.02010431,0.8804408,0.001974996,0.008417171,0.00003093515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968979,0.0004469039,0.001329873,0.0001219325,0.00001584345,0.00001060231,0.00003449717,0.00001598498,0.001126482],"genre_scores_gemma":[0.9990366,0.00009831473,0.0004517675,0.0000785891,0.000005470903,0.000002987049,0.00006025997,0.000002682905,0.0002634207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009895571,"threshold_uncertainty_score":0.003310382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05240716889866898,"score_gpt":0.3885701412682315,"score_spread":0.3361629723695626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}