{"id":"W3215838857","doi":"10.1007/s00213-021-06029-w","title":"Anxiety and cognitive-related effects of Δ 9-tetrahydrocannabinol (THC) are differentially mediated through distinct GSK-3 vs. Akt-mTOR pathways in the nucleus accumbens of male rats","year":2021,"lang":"en","type":"article","venue":"Psychopharmacology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Nucleus accumbens; Neuroscience; Psychology; Sensory gating; Schizophrenia (object-oriented programming); Anxiety; Tetrahydrocannabinol; Amygdala; Cognition; Cannabinoid; Psychiatry; Medicine; Gating; Dopamine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009122219,0.0006874353,0.000508274,0.0009250701,0.0005037969,0.0004525923,0.0003097352,0.0003517866,0.004112866],"category_scores_gemma":[0.0001327901,0.000426542,0.0004685875,0.0002234558,0.001024174,0.0005121612,0.000290513,0.001267987,0.0003569926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001064649,"about_ca_system_score_gemma":0.0009175377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01089596,"about_ca_topic_score_gemma":0.03172174,"domain_scores_codex":[0.9998137,0.00001182485,0.000008616001,0.00003943529,0.00004354611,0.00008294723],"domain_scores_gemma":[0.9997886,0.00000822789,0.00005847636,0.00001659577,0.00002567331,0.0001025132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007325335,0.0005220244,0.001346417,0.00006918414,0.00006038654,0.000140921,0.0001332223,0.00009463613,0.9861967,0.000282993,0.0001760449,0.003652106],"study_design_scores_gemma":[0.0004463818,0.003272471,0.08524683,0.00003476446,0.0002407569,0.0003116993,0.0007488189,0.001517315,0.9061959,0.0006367664,0.00126418,0.00008413485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982092,0.0003223921,0.0002837992,0.0001701963,0.00003678578,0.00001011333,0.0003472575,0.00003726401,0.0005829164],"genre_scores_gemma":[0.9914762,0.0007733639,0.0006800011,0.0001037151,0.00001560878,0.00005310127,0.0003685231,0.00004094448,0.006488516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01089596,"threshold_uncertainty_score":0.0216651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0158577924208143,"score_gpt":0.3098212714044535,"score_spread":0.2939634789836392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}