{"id":"W3215865402","doi":"10.3389/fonc.2021.777834","title":"Estrogen Receptor 1 Inhibition of Wnt/β-Catenin Signaling Contributes to Sex Differences in Hepatocarcinogenesis","year":2021,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"Toronto General Hospital Research Institute, University Health Network; University of Toronto; Canadian Liver Foundation","keywords":"Wnt signaling pathway; Estrogen receptor; Estrogen receptor alpha; Cancer research; Cyclin D1; Biology; Catenin; Estrogen; Signal transduction; Internal medicine; Endocrinology; Cancer; Medicine; Cell cycle; Breast cancer; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003785426,0.0001667273,0.0004426431,0.0001875107,0.00003155639,0.00001012157,0.0001631282,0.000295116,0.00004392452],"category_scores_gemma":[0.00015471,0.0001780192,0.0000736512,0.0003942639,0.00009105614,0.000004784911,0.0001259422,0.0001107041,0.000003948905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001533232,"about_ca_system_score_gemma":0.0004186108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004374513,"about_ca_topic_score_gemma":0.00006425828,"domain_scores_codex":[0.9984133,0.0002016923,0.0005027409,0.0004304068,0.0001205643,0.0003313449],"domain_scores_gemma":[0.9995155,0.00003421132,0.0001195639,0.0001372939,0.0001296659,0.00006380303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001966442,0.0000831141,0.4427527,0.00001539053,0.00004748483,0.00001490054,0.0002007243,0.00009698599,0.5503414,0.00002997011,0.003449804,0.002770858],"study_design_scores_gemma":[0.001091894,0.0002630496,0.009641632,0.00006785026,0.00001504136,0.000003748798,0.0009618195,0.00004129235,0.9821511,0.0003704982,0.005180248,0.0002118142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907536,0.0034484,0.004279093,0.000397426,0.0006402219,0.0002185403,0.00001770183,0.000007466219,0.0002375393],"genre_scores_gemma":[0.9887485,0.0003916819,0.009824243,0.0003123193,0.00009088767,0.0001231697,0.0001454336,0.00001779064,0.0003459711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.433111,"threshold_uncertainty_score":0.7259411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01395532329380631,"score_gpt":0.2499363265892475,"score_spread":0.2359810032954412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}