{"id":"W3215893398","doi":"10.1186/s13058-021-01487-8","title":"Periostin gene expression in neu-positive breast cancer cells is regulated by a FGFR signaling cross talk with TGFβ/PI3K/AKT pathways","year":2021,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Lunenfeld-Tanenbaum Research Institute; University of Ottawa","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Surgical oncology; Periostin; Cancer research; PI3K/AKT/mTOR pathway; Breast cancer; Protein kinase B; Medicine; Signal transduction; Gene; Cancer; Oncology; Internal medicine; Biology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007063934,0.0001596832,0.0001038786,0.0001898877,0.0001124581,0.0001779897,0.00006500114,0.0001166591,0.001170282],"category_scores_gemma":[0.00006345366,0.00007428477,0.0001570608,0.0001294231,0.0001137843,0.00009929343,0.0001189254,0.0002623103,0.0002781794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002498302,"about_ca_system_score_gemma":0.0001908465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005719,"about_ca_topic_score_gemma":0.0009140461,"domain_scores_codex":[0.999925,0.000006329375,0.000004904349,0.00001360053,0.00002959591,0.00002060195],"domain_scores_gemma":[0.9999275,0.00001144473,0.00002532145,0.000006341868,0.00001284495,0.00001657678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007317575,0.00001037617,0.0004920635,0.0000134302,0.000001574038,0.00002930397,0.000008157006,0.0000167171,0.9987796,0.00002945642,0.00002288979,0.000523181],"study_design_scores_gemma":[0.00001152988,0.000200935,0.05663632,0.000006375581,0.00001218976,0.0004463463,0.0000560991,0.0007990546,0.9392037,0.00003947708,0.002583798,0.00000423584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995691,0.001231522,0.0009247123,0.00005452575,0.00001238595,0.000012846,0.0003563669,0.00003980031,0.001676925],"genre_scores_gemma":[0.9954457,0.0005186947,0.00104913,0.00003437006,0.000006156263,0.00003324158,0.000561612,0.000007081302,0.002343999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001170282,"threshold_uncertainty_score":0.003914952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02952735859563818,"score_gpt":0.3393221274474222,"score_spread":0.309794768851784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}