{"id":"W3215896415","doi":"10.1093/neuonc/noab196.015","title":"EPCO-16. ONCOHISTONE INTERACTOME PROFILING UNCOVERS MECHANISMS OF CHROMATIN DISRUPTION AND IDENTIFIES POTENTIAL THERAPEUTIC TARGETS IN PEDIATRIC HIGH-GRADE GLIOMA","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Hospital for Sick Children","funders":"","keywords":"Methyltransferase; Chromatin; Epigenetics; Histone; Methylation; PRC2; DNA methylation; Biology; Mutant; EZH2; Transcription factor; Histone methylation; Histone H3; Genetics; Cell biology; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008102742,0.0002038382,0.0001901803,0.0004216774,0.0001269913,0.0002270765,0.000143306,0.0002026688,0.001808413],"category_scores_gemma":[0.00008326236,0.000102186,0.0001395905,0.0003182343,0.0001150962,0.0001044674,0.0001736991,0.0001845525,0.0003779916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003148675,"about_ca_system_score_gemma":0.0001537199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000979249,"about_ca_topic_score_gemma":0.001848646,"domain_scores_codex":[0.9999137,0.000005262522,0.000003704173,0.00001879362,0.00003765001,0.00002085421],"domain_scores_gemma":[0.999943,0.000007800618,0.00001857435,0.00000465638,0.00000791242,0.00001809488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003571508,0.00002155626,0.008433511,0.00006764003,0.00002038972,0.0001038057,0.00001551195,0.0003204886,0.9834082,0.00007921409,0.0002494512,0.00692312],"study_design_scores_gemma":[0.00002930608,0.0004904169,0.1508306,0.00001337997,0.00006483503,0.001432052,0.00009220771,0.004276397,0.8322921,0.0001343015,0.01033391,0.00001056201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926237,0.001345216,0.001787118,0.00006614973,0.000007365293,0.00002649429,0.002530519,0.0001314848,0.001482141],"genre_scores_gemma":[0.9908277,0.0005917351,0.002174648,0.00005509602,0.000002397235,0.00003987907,0.003679242,0.00002363449,0.002605659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001808413,"threshold_uncertainty_score":0.006049693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0112207558963484,"score_gpt":0.2827014592532061,"score_spread":0.2714807033568576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}