{"id":"W3215940754","doi":"10.3390/molecules26237132","title":"Design, Synthesis and Tumour-Selective Toxicity of Novel 1-[3-{3,5-Bis(benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone Oximes and Related Quaternary Ammonium Salts","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute of General Medical Sciences; Japan Society for the Promotion of Science","keywords":"Cytotoxicity; Chemistry; Stereochemistry; Toxicity; Selectivity; Cytotoxic T cell; Ammonium; Potency; In vitro; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002616465,0.0003714862,0.0006549325,0.00005541032,0.0001626686,0.00006891465,0.0001868881,0.0003220171,0.0002412043],"category_scores_gemma":[0.0007841517,0.0003008396,0.0001319014,0.0001924671,0.0003136688,0.00012367,0.0002631999,0.0002625266,0.000003075084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000514688,"about_ca_system_score_gemma":0.00008030528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001612714,"about_ca_topic_score_gemma":0.00001815083,"domain_scores_codex":[0.9979939,0.0001557256,0.0004449431,0.0007508446,0.0002573364,0.0003972816],"domain_scores_gemma":[0.9981576,0.000971068,0.0002373957,0.0003208637,0.0001501965,0.0001628903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002556344,0.0004509619,0.002767312,0.0001184951,0.0001641794,0.00008989157,0.0001556237,0.00001297586,0.989962,0.0001042183,0.00003167212,0.005886993],"study_design_scores_gemma":[0.0004294759,0.00008103315,0.008148097,0.0001543422,0.00009637034,0.0001364486,0.0002672497,0.001320136,0.9886433,0.0002931724,0.00004890538,0.0003815054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939818,0.002331019,0.0011425,0.0003248561,0.00004378616,0.0001091781,0.00007021666,0.00009198009,0.001904656],"genre_scores_gemma":[0.9959981,0.0004841911,0.00311042,0.00005467764,0.00004583252,0.00003934172,0.000009617164,0.00003646871,0.000221357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005505487,"threshold_uncertainty_score":0.9999444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02267192246598631,"score_gpt":0.2265384097481016,"score_spread":0.2038664872821153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}