{"id":"W3215940754","doi":"10.3390/molecules26237132","title":"Design, Synthesis and Tumour-Selective Toxicity of Novel 1-[3-{3,5-Bis(benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone Oximes and Related Quaternary Ammonium Salts","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute of General Medical Sciences; Japan Society for the Promotion of Science","keywords":"Cytotoxicity; Chemistry; Stereochemistry; Toxicity; Selectivity; Cytotoxic T cell; Ammonium; Potency; In vitro; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001527321,0.0003710399,0.0002656228,0.0002011357,0.000114144,0.0001936896,0.000356991,0.0002392501,0.001035696],"category_scores_gemma":[0.0001499069,0.0001621368,0.0001594954,0.0001394127,0.0001793723,0.0002290503,0.0001666482,0.0003370466,0.0003204232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002234389,"about_ca_system_score_gemma":0.0002671349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002402456,"about_ca_topic_score_gemma":0.000528598,"domain_scores_codex":[0.9999557,0.000009302249,0.00000544449,0.00000959414,0.000008844337,0.00001116033],"domain_scores_gemma":[0.999931,0.000007411473,0.00002424246,0.000005831985,0.00001299792,0.00001863655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002069225,0.0002259059,0.0001753637,0.0002039178,0.0000121191,0.0001387863,0.0000516553,0.001336075,0.983041,0.0005689054,0.0001674085,0.01387192],"study_design_scores_gemma":[0.0001088062,0.002882557,0.00101908,0.00001144948,0.00002996162,0.0002041513,0.00001521164,0.001418871,0.9886342,0.00005841625,0.00560557,0.00001165875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852261,0.002048855,0.008517764,0.0001061877,0.00004218405,0.0003254594,0.0003269833,0.0001140606,0.003292373],"genre_scores_gemma":[0.9826133,0.00224678,0.01066932,0.00006981705,0.00001970673,0.0002046075,0.0003747836,0.00001809749,0.003783628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001035696,"threshold_uncertainty_score":0.003464758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02267192246598631,"score_gpt":0.2265384097481016,"score_spread":0.2038664872821153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}