{"id":"W3215972394","doi":"10.1016/j.theriogenology.2021.11.022","title":"Protegrin-1 inhibits porcine ovarian granulosa cell apoptosis from H2O2-induced oxidative stress via the PERK/eIF2α/CHOP signaling pathway in vitro","year":2021,"lang":"en","type":"article","venue":"Theriogenology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"","keywords":"Follicular atresia; Apoptosis; CHOP; Oxidative stress; Cell biology; Biology; Endoplasmic reticulum; Granulosa cell; Unfolded protein response; Molecular biology; Chemistry; Ovary; Endocrinology; Ovarian follicle; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000138793,0.0002362565,0.0002774754,0.0001961411,0.0001804563,0.0001966405,0.0001445601,0.0002168496,0.0009272745],"category_scores_gemma":[0.0001017236,0.000115431,0.0002609148,0.0001447032,0.0002322599,0.000142193,0.0001580249,0.0005458416,0.0001733579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002084215,"about_ca_system_score_gemma":0.0003468109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000652327,"about_ca_topic_score_gemma":0.001237578,"domain_scores_codex":[0.9999192,0.00001266842,0.000007290653,0.00001341043,0.00001568817,0.00003171812],"domain_scores_gemma":[0.9999599,0.000009228006,0.000009743948,0.000005839055,0.000003622842,0.00001165391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001299049,0.0001547045,0.000189397,0.0001149635,0.0000145914,0.00009498091,0.00003923392,0.0001672784,0.9948431,0.00007782472,0.0001330268,0.002871678],"study_design_scores_gemma":[0.0002251387,0.001898609,0.006544956,0.0000139657,0.00003948551,0.0002209895,0.0000905741,0.0007084117,0.9854445,0.0000685599,0.004737778,0.000007214847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943369,0.002493179,0.00102548,0.0002161036,0.00009891405,0.00004022084,0.000261114,0.00005580767,0.001472288],"genre_scores_gemma":[0.9952218,0.001374761,0.0007531128,0.0001036779,0.00001995335,0.00003941547,0.0004640136,0.000009848231,0.002013451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009272745,"threshold_uncertainty_score":0.003102005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412698301519646,"score_gpt":0.2225918659412794,"score_spread":0.2084648829260829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}