{"id":"W3216010712","doi":"10.1016/j.antiviral.2021.105209","title":"2-((1H-indol-3-yl)thio)-N-phenyl-acetamides: SARS-CoV-2 RNA-dependent RNA polymerase inhibitors","year":2021,"lang":"en","type":"article","venue":"Antiviral Research","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fundamental Research Funds for the Central Universities; National Key Research and Development Program of China; National Infrastructure for Microbiological Resources; Chinese Academy of Medical Sciences; National Natural Science Foundation of China","keywords":"Virology; RNA polymerase; Exoribonuclease; RNA-dependent RNA polymerase; Thio-; Coronavirus; Biology; Virus; Viral replication; RNA; Medicine; Coronavirus disease 2019 (COVID-19); Gene; Chemistry; Disease; Biochemistry; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002236958,0.0006523991,0.0003979767,0.0002942667,0.0001621957,0.0001503245,0.0003565819,0.0003495016,0.001963048],"category_scores_gemma":[0.0001501021,0.000172345,0.0002837781,0.0003453074,0.0001596994,0.0002685722,0.0001792463,0.000598054,0.0006331031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001749662,"about_ca_system_score_gemma":0.0002311956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000344783,"about_ca_topic_score_gemma":0.001138322,"domain_scores_codex":[0.9997883,0.00003930742,0.00001830649,0.00004748144,0.00005869134,0.00004793807],"domain_scores_gemma":[0.9999201,0.00001908755,0.00002105319,0.000009536403,0.00001345857,0.00001665986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003169919,0.0004330961,0.0002313434,0.0003503601,0.00002565389,0.0001497474,0.00003715533,0.0008943086,0.9840794,0.0003723823,0.0005219216,0.01258759],"study_design_scores_gemma":[0.0001955574,0.004465401,0.00207122,0.00002754504,0.00003648148,0.0004791806,0.00003308067,0.001298512,0.9823293,0.00008571124,0.008951808,0.00002607977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9474947,0.01472026,0.01701649,0.0003805835,0.0002364988,0.0006436016,0.002129348,0.0004920558,0.01688648],"genre_scores_gemma":[0.9676476,0.008971178,0.01382488,0.0003623554,0.0000497663,0.0005468869,0.001804646,0.00003785482,0.006754952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001963048,"threshold_uncertainty_score":0.006567061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1042405548929166,"score_gpt":0.4223945402369167,"score_spread":0.3181539853440001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}