{"id":"W3216010712","doi":"10.1016/j.antiviral.2021.105209","title":"2-((1H-indol-3-yl)thio)-N-phenyl-acetamides: SARS-CoV-2 RNA-dependent RNA polymerase inhibitors","year":2021,"lang":"en","type":"article","venue":"Antiviral Research","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fundamental Research Funds for the Central Universities; National Key Research and Development Program of China; National Infrastructure for Microbiological Resources; Chinese Academy of Medical Sciences; National Natural Science Foundation of China","keywords":"Virology; RNA polymerase; Exoribonuclease; RNA-dependent RNA polymerase; Thio-; Coronavirus; Biology; Virus; Viral replication; RNA; Medicine; Coronavirus disease 2019 (COVID-19); Gene; Chemistry; Disease; Biochemistry; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003521457,0.0005736916,0.0009716602,0.001090062,0.0006587934,0.0004738098,0.0007971316,0.0005017419,0.0000801611],"category_scores_gemma":[0.002992754,0.0005230193,0.0005285206,0.002793827,0.0008450554,0.0005292331,0.001177503,0.002911689,0.003002731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005703332,"about_ca_system_score_gemma":0.003001198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002006315,"about_ca_topic_score_gemma":0.0004710362,"domain_scores_codex":[0.9893627,0.001118176,0.000884058,0.001573447,0.004548391,0.002513246],"domain_scores_gemma":[0.9955338,0.000909348,0.0001182913,0.001756185,0.001511163,0.0001712497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008447267,0.0008288434,0.008995192,0.0002932989,0.0002197609,0.006110753,0.0005070037,4.681075e-8,0.9415004,0.0005567208,0.01007155,0.03007174],"study_design_scores_gemma":[0.003214273,0.0006857989,0.001244329,0.0003713654,0.00004846727,0.0001596564,0.001199215,0.0001459424,0.9431491,0.0004255685,0.04887617,0.00048006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9361744,0.003047092,0.00006800851,0.002945288,0.0004814224,0.0009841695,0.00003528731,0.0002072714,0.05605707],"genre_scores_gemma":[0.981091,0.0002065339,0.0001659437,0.01383732,0.001184229,0.0001399274,0.00002838728,0.0001630917,0.0031836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05287347,"threshold_uncertainty_score":0.9997221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1042405548929166,"score_gpt":0.4223945402369167,"score_spread":0.3181539853440001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}