{"id":"W3216011696","doi":"10.1016/j.actbio.2021.11.021","title":"α-Linolenic acid and linoleic acid modulate the lipidome and the skin barrier of a tissue-engineered skin model","year":2021,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"Docosapentaenoic acid; Linoleic acid; Barrier function; Eicosapentaenoic acid; Polyunsaturated fatty acid; Phospholipid; Biochemistry; Fatty acid; Chemistry; Human skin; Food science; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005406188,0.0002866448,0.0003956901,0.00005435927,0.0002552875,0.0000534483,0.0003297642,0.0002811228,0.0003805842],"category_scores_gemma":[0.00005589229,0.0001883662,0.00007448968,0.000163516,0.0007418596,0.0001520082,0.0002652052,0.0002650222,0.00001467006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002027177,"about_ca_system_score_gemma":0.00005575755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001488533,"about_ca_topic_score_gemma":0.000008544807,"domain_scores_codex":[0.9981255,0.0004877806,0.0004582113,0.0003679186,0.0001670712,0.0003935176],"domain_scores_gemma":[0.999072,0.0001596238,0.0001455404,0.0004141181,0.00009108407,0.0001176591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006172391,0.00007084278,0.00003623017,0.000109635,0.0003273668,0.0000162075,0.00195786,0.0003003399,0.9911602,0.000880716,0.0004880474,0.004035305],"study_design_scores_gemma":[0.003734893,0.00004817859,0.0003497534,0.00002252342,0.0003073571,0.0000644726,0.0001347715,0.01850748,0.9656417,0.001176797,0.009774328,0.0002376963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914122,0.003008834,0.0008406912,0.001841034,0.001933085,0.0004683257,0.0002977676,0.00004842229,0.0001496919],"genre_scores_gemma":[0.995829,0.001888338,0.0004762939,0.0008559384,0.0002390969,0.0000581235,0.00003500117,0.00003450579,0.000583638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02551846,"threshold_uncertainty_score":0.7681352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0415322654284958,"score_gpt":0.3553442278977401,"score_spread":0.3138119624692443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}