{"id":"W3216054793","doi":"10.1080/19420862.2021.2003281","title":"Agonistic nanobodies and antibodies to human VISTA","year":2021,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research","keywords":"Monoclonal antibody; Epitope; Immune system; Antibody; Molecular biology; Splenocyte; Chemistry; Peripheral blood mononuclear cell; Biology; Immunology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003428591,0.001011946,0.0003389741,0.000329801,0.000205545,0.0003530254,0.0004796407,0.0007436671,0.001829949],"category_scores_gemma":[0.0002032814,0.0003312891,0.0004752672,0.0002048086,0.0002031174,0.0002199519,0.0004253442,0.001203775,0.001058484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005312942,"about_ca_system_score_gemma":0.0002001237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002459156,"about_ca_topic_score_gemma":0.000492172,"domain_scores_codex":[0.9993505,0.0001421905,0.00005558775,0.0001689598,0.0001520744,0.0001306346],"domain_scores_gemma":[0.9998285,0.00004493044,0.00003405448,0.00002944262,0.00003217845,0.00003084242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000050558,0.00003992995,0.0000764111,0.00004339071,0.000006947188,0.00002489937,0.00001408881,0.00007199232,0.9982534,0.0001213072,0.00008904969,0.001208008],"study_design_scores_gemma":[0.00002540734,0.0004340342,0.001021103,0.00001572197,0.00002839762,0.000410646,0.00001896986,0.0007208695,0.9855679,0.00004210462,0.01170766,0.000007102018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9610766,0.006536289,0.02282876,0.000274305,0.0001739027,0.0003949698,0.0006734835,0.0002841293,0.007757468],"genre_scores_gemma":[0.9641583,0.004275448,0.01953995,0.0004892866,0.0001390107,0.0006483823,0.002857976,0.00007537367,0.007816399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001829949,"threshold_uncertainty_score":0.006121814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03276743611031343,"score_gpt":0.3527835085661249,"score_spread":0.3200160724558115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}