{"id":"W3216073603","doi":"10.1073/pnas.2105927118","title":"Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Biology; Viremia; Retinoic acid; Viral replication; Enhancer; Transcription factor; Gene expression; Virology; Molecular biology; Gene; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001546367,0.0002767636,0.0002169371,0.0002931975,0.0002388485,0.0005559929,0.000149892,0.0002511233,0.0024063],"category_scores_gemma":[0.0001355663,0.0001361293,0.0002505092,0.0001161935,0.0003118062,0.0002305353,0.0002348376,0.0006418322,0.0009164372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003667051,"about_ca_system_score_gemma":0.0002058703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000293644,"about_ca_topic_score_gemma":0.0005013974,"domain_scores_codex":[0.9997619,0.00004308985,0.0000108207,0.00004999902,0.00004784596,0.00008640096],"domain_scores_gemma":[0.9998542,0.0000215216,0.00003654596,0.00001752025,0.00002250035,0.00004755449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008481287,0.00001650565,0.0005228948,0.00001942474,0.000002710282,0.00005592583,0.00001594844,0.00004654139,0.9976936,0.0001649139,0.00008529005,0.00129133],"study_design_scores_gemma":[0.00002057037,0.0001813736,0.01514008,0.00001479106,0.00001337769,0.0004629027,0.0000955543,0.001483728,0.9765013,0.0001615369,0.005919191,0.000005598765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832888,0.006472634,0.003628933,0.0002453368,0.00007753997,0.00003063735,0.0005295041,0.0001467694,0.005579772],"genre_scores_gemma":[0.9912901,0.001211928,0.002196772,0.00007195403,0.00002739038,0.00002845683,0.0004002957,0.00004571103,0.004727373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0024063,"threshold_uncertainty_score":0.008049846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0306043035757184,"score_gpt":0.2498235958865342,"score_spread":0.2192192923108158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}