{"id":"W3216093367","doi":"10.3390/ijms222212596","title":"Selectivity Determinants of RHO GTPase Binding to IQGAPs","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft","keywords":"RHOA; GTPase; CDC42; IQGAP1; Effector; Cell biology; RAC1; Biology; GTPase-activating protein; Ras superfamily; Peptide sequence; Plasma protein binding; Chemistry; Biochemistry; G protein; Signal transduction; Gene; Scaffold protein; GTP'","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002168581,0.0002583284,0.0002573878,0.0002580396,0.0001665959,0.0003234288,0.000256679,0.0002426385,0.001819243],"category_scores_gemma":[0.000366736,0.0001262039,0.0002290776,0.00009393758,0.0002318327,0.0001432748,0.0002921124,0.0003393173,0.0006491591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002364034,"about_ca_system_score_gemma":0.0001528944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003410184,"about_ca_topic_score_gemma":0.0003633368,"domain_scores_codex":[0.9997424,0.00006109531,0.00001274601,0.00004597676,0.00006650173,0.00007126367],"domain_scores_gemma":[0.9996701,0.00008602831,0.00006399718,0.00002286072,0.00004424107,0.0001127343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001394692,0.00001955673,0.001160051,0.00001030634,0.000005327578,0.0000838015,0.00001620815,0.0001177991,0.9974347,0.0002230074,0.00002694623,0.00076281],"study_design_scores_gemma":[0.00004791357,0.0003984727,0.0622096,0.000009633779,0.00004471371,0.001452599,0.0001402892,0.008519914,0.9250137,0.0003005215,0.001835604,0.00002696625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998121,0.0001192469,0.0008496285,0.00002314519,0.000004825209,0.000006010518,0.0000308853,0.00001624238,0.0008289731],"genre_scores_gemma":[0.999493,0.00003228974,0.0002256485,0.00001582467,0.000002362092,0.000003787904,0.00006483845,0.000004593578,0.0001576104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001819243,"threshold_uncertainty_score":0.006085992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01633125683904377,"score_gpt":0.3097782636602808,"score_spread":0.293447006821237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}