{"id":"W3216093367","doi":"10.3390/ijms222212596","title":"Selectivity Determinants of RHO GTPase Binding to IQGAPs","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft","keywords":"RHOA; GTPase; CDC42; IQGAP1; Effector; Cell biology; RAC1; Biology; GTPase-activating protein; Ras superfamily; Peptide sequence; Plasma protein binding; Chemistry; Biochemistry; G protein; Signal transduction; Gene; Scaffold protein; GTP'","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005019504,0.00007039445,0.0001155078,0.0001424957,0.00004158418,0.00004110942,0.0003366247,0.0000404181,0.00002326187],"category_scores_gemma":[0.0003694693,0.00006413757,0.0001144971,0.0002003669,0.00007243419,0.00001273921,0.0001084984,0.00005025923,0.000001944855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001652008,"about_ca_system_score_gemma":0.0002992779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004800036,"about_ca_topic_score_gemma":0.0000093993,"domain_scores_codex":[0.9988996,0.00006763707,0.0002851796,0.0001536909,0.0004847777,0.0001091591],"domain_scores_gemma":[0.9989687,0.00001234589,0.0002361017,0.00008327135,0.0006237433,0.00007586796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003277274,0.00004644734,0.004038099,0.000003313121,0.00003255306,0.0001181535,0.00003037926,0.0009342556,0.9881005,0.000117827,0.0000469818,0.006498775],"study_design_scores_gemma":[0.0002341591,0.0001688193,0.001295746,0.00006379306,0.000007316889,0.0002823859,0.00005373549,0.0001170111,0.9962661,0.0001751303,0.001262964,0.00007288554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900163,0.0004992186,0.008607008,0.0002980116,0.0002953486,0.00003443306,0.000006603126,0.000001452762,0.0002415902],"genre_scores_gemma":[0.9934762,0.00003203898,0.00611331,0.0002220797,0.0001020926,9.644627e-7,0.000002359927,0.000004589434,0.00004641362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008165611,"threshold_uncertainty_score":0.2615454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01633125683904377,"score_gpt":0.3097782636602808,"score_spread":0.293447006821237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}