{"id":"W3216134940","doi":"10.3389/fphys.2021.774025","title":"Unsuccessful and Successful Clinical Trials in Acute Respiratory Distress Syndrome: Addressing Physiology-Based Gaps","year":2021,"lang":"en","type":"review","venue":"Frontiers in Physiology","topic":"Respiratory Support and Mechanisms","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"European Regional Development Fund; Instituto de Salud Carlos III","keywords":"Medicine; ARDS; Anesthesia; Mechanical ventilation; Fraction of inspired oxygen; Hypoxemia; Oxygenation; Positive end-expiratory pressure; Extracorporeal membrane oxygenation; Ventilation (architecture); Lung; Tidal volume; Respiratory system; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02326053,0.001192921,0.004471905,0.001605519,0.0005343118,0.002936112,0.001415989,0.002996597,0.004368164],"category_scores_gemma":[0.03893906,0.0003729439,0.004302792,0.001916662,0.001373496,0.002351513,0.001248828,0.002267056,0.0007740193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001152042,"about_ca_system_score_gemma":0.002368362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003377218,"about_ca_topic_score_gemma":0.0007953046,"domain_scores_codex":[0.9864267,0.007498721,0.003679607,0.0008409767,0.001288083,0.0002658814],"domain_scores_gemma":[0.9676831,0.02437324,0.003758285,0.001037627,0.002606332,0.0005412921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.01334259,0.00086346,0.001395354,0.2425044,0.01490873,0.0003125175,0.0004224494,0.0005793445,0.003300107,0.00675734,0.009826753,0.7057869],"study_design_scores_gemma":[0.0416991,0.03278243,0.01070357,0.305874,0.07193303,0.00210627,0.001191082,0.001067099,0.006597584,0.01213734,0.5136732,0.0002352737],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003960798,0.9884509,0.001278347,0.002591599,0.001213353,0.0009891646,0.0001730502,0.00003239106,0.001310358],"genre_scores_gemma":[0.06275629,0.9053448,0.01066793,0.01394606,0.00264645,0.003037841,0.0004515719,0.00006249759,0.001086536],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02326053,"threshold_uncertainty_score":0.1230149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1490721549383794,"score_gpt":0.4477355244754394,"score_spread":0.29866336953706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}