{"id":"W3216151293","doi":"10.1093/neuonc/noab196.692","title":"EXTH-53. ANTI-ROBO1 CAR T CELLS EFFECTIVELY TARGET MALIGNANT BRAIN CANCER","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; McMaster University","funders":"","keywords":"Downregulation and upregulation; Cancer research; Chimeric antigen receptor; Glioma; Cancer; Degranulation; Medicine; Antigen; Antibody; Brain tumor; Cancer cell; Immunology; Immunotherapy; Biology; Receptor; Pathology; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006845948,0.0003620999,0.0002918507,0.0001947129,0.000118908,0.0003343723,0.0001375257,0.0002694974,0.002241125],"category_scores_gemma":[0.00005405978,0.00007895435,0.0001867484,0.0001015261,0.0001740861,0.0001784565,0.0001307969,0.0006354628,0.0005762436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002733201,"about_ca_system_score_gemma":0.0002850025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001025354,"about_ca_topic_score_gemma":0.001603713,"domain_scores_codex":[0.9999211,0.000006533393,0.000004004615,0.00001512756,0.0000130894,0.00004010319],"domain_scores_gemma":[0.9999714,0.000004972613,0.000004691902,0.000003613632,0.000003372869,0.00001199652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003652396,0.0003318437,0.0004677392,0.0001023094,0.00002012851,0.0001567737,0.00004104281,0.0005315077,0.9793985,0.0005551482,0.001404024,0.0166259],"study_design_scores_gemma":[0.0001554327,0.002409929,0.004480383,0.00001601966,0.00006123186,0.0007236007,0.00004572416,0.002638731,0.97332,0.0001652226,0.01597524,0.000008441446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817615,0.003460765,0.00461399,0.000453951,0.000113393,0.000154481,0.0006857562,0.0004653991,0.008290784],"genre_scores_gemma":[0.9919247,0.001005529,0.001415988,0.0001147201,0.00002025645,0.00008629206,0.0004338564,0.00002500846,0.004973657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002241125,"threshold_uncertainty_score":0.00749737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02928900314783732,"score_gpt":0.3489784364317776,"score_spread":0.3196894332839403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}