{"id":"W3216154736","doi":"10.1101/2021.11.22.469570","title":"Co-Delivery of Synergistic Antimicrobials with Polyelectrolyte Nanocomplexes to Treat Bacterial Biofilms and Lung Infections","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"University of California, San Francisco; National Institutes of Health; Cystic Fibrosis Foundation; National Science Foundation","keywords":"Antimicrobial; Biofilm; Tobramycin; Pseudomonas aeruginosa; Microbiology; Drug delivery; Cystic fibrosis; Antibiotics; Antibiotic resistance; Polyelectrolyte; Drug resistance; Chemistry; Lung infection; Medicine; Bacteria; Nanotechnology; Lung; Biology; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000176935,0.0002968815,0.0002971247,0.0002423054,0.00009229634,0.0002421539,0.0001335625,0.0003258279,0.0007694477],"category_scores_gemma":[0.0001447882,0.0001107222,0.0002127453,0.0001140232,0.0001624909,0.0001988427,0.0002673235,0.0003379021,0.0003452376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002176316,"about_ca_system_score_gemma":0.0001684816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003432885,"about_ca_topic_score_gemma":0.0005196963,"domain_scores_codex":[0.9998852,0.00001740757,0.000008764696,0.00002728876,0.00004121411,0.00001997843],"domain_scores_gemma":[0.9999446,0.00001198057,0.00001190899,0.000006594059,0.000009778922,0.00001520689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003226016,0.00002435055,0.00003662059,0.00002367964,0.000005271744,0.00001659917,0.000005725152,0.0001378165,0.9978349,0.00004710193,0.00007570542,0.001760081],"study_design_scores_gemma":[0.00001470603,0.0001684951,0.0003272534,0.000003810009,0.00001040844,0.00005949987,0.000004224875,0.001621765,0.9957344,0.00002050304,0.002031493,0.000003447828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787791,0.004021023,0.0136768,0.0003033291,0.0001452408,0.0001028156,0.0001624766,0.0002352685,0.002573942],"genre_scores_gemma":[0.9824759,0.001026171,0.01232213,0.000106928,0.00003294908,0.00007948762,0.0001173206,0.00005334969,0.003785819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007694477,"threshold_uncertainty_score":0.002574027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009842696167170654,"score_gpt":0.2304242305272047,"score_spread":0.2205815343600341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}