{"id":"W3216161881","doi":"10.1158/1535-7163.mct-21-0411","title":"Cyclin-dependent Kinase 4/6 Inhibitor Palbociclib in Combination with Ralaniten Analogs for the Treatment of Androgen Receptor–positive Prostate and Breast Cancers","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"National Cancer Institute; National Institutes of Health","keywords":"Palbociclib; Prostate; Androgen receptor; Medicine; Cyclin-dependent kinase 4; Internal medicine; Kinase; Cancer research; Androgen; Oncology; Endocrinology; Prostate cancer; Pharmacology; Breast cancer; Biology; Cancer; Cyclin-dependent kinase 2; Hormone; Cell cycle; Metastatic breast cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001158467,0.000348321,0.0005490742,0.0004909758,0.0001737109,0.0002604083,0.0003737436,0.0002178585,0.002115304],"category_scores_gemma":[0.0000719317,0.0001322659,0.000292395,0.0003044861,0.0001627701,0.0001360544,0.000141313,0.0008574933,0.0005045841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005014237,"about_ca_system_score_gemma":0.0004281978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001235888,"about_ca_topic_score_gemma":0.00421879,"domain_scores_codex":[0.9999181,0.00001449033,0.00000572287,0.00001107291,0.0000265438,0.0000240826],"domain_scores_gemma":[0.9999624,0.000004196797,0.000007193901,0.00000355927,0.000006240235,0.0000164381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004994352,0.002031211,0.0009429319,0.0005087114,0.0001418607,0.000364894,0.00004949967,0.0009104782,0.8433326,0.0005475872,0.004543968,0.1416319],"study_design_scores_gemma":[0.003382642,0.01851782,0.01723114,0.00007431241,0.000358193,0.002687383,0.0000688872,0.004185678,0.8746428,0.0002491848,0.07855307,0.00004877865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9318079,0.04584612,0.002647103,0.001084258,0.0004245591,0.0004893408,0.001045887,0.0005603326,0.01609447],"genre_scores_gemma":[0.9856014,0.007080598,0.00179688,0.0001927407,0.00008005892,0.000148652,0.0008642983,0.00003613907,0.00419929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002115304,"threshold_uncertainty_score":0.007076442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01421695393868247,"score_gpt":0.2829275605301325,"score_spread":0.2687106065914501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}