{"id":"W3216179038","doi":"10.1016/j.cbpa.2021.102099","title":"New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance","year":2021,"lang":"en","type":"review","venue":"Current Opinion in Chemical Biology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Antibiotics; Bacteria; Potentiator; Gram-negative bacteria; Antibiotic resistance; Bacterial outer membrane; Microbiology; Membrane permeability; Biology; Chemistry; Membrane; Biochemistry; Pharmacology; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002872498,0.0005066762,0.002086791,0.0002024037,0.00007146451,0.00001602753,0.0005493377,0.0006847374,0.0001562131],"category_scores_gemma":[0.0005837946,0.0003453644,0.0005262332,0.0005138275,0.000409432,0.00004834848,0.0005467647,0.001150799,0.0000806077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001286977,"about_ca_system_score_gemma":0.000238765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006465964,"about_ca_topic_score_gemma":0.000004505843,"domain_scores_codex":[0.9971359,0.0006439797,0.0009514587,0.0007106651,0.00004155224,0.0005164542],"domain_scores_gemma":[0.9977998,0.00114837,0.0005301493,0.0003781484,0.00009839761,0.00004510119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001345032,0.0003064042,0.0001199454,0.0109814,0.0007473588,0.000002287559,0.0006098906,9.41233e-7,0.01731718,0.003659301,0.03256983,0.933551],"study_design_scores_gemma":[0.0004558102,0.00005844968,0.00000839648,0.01224573,0.0001203228,0.00001558005,0.00007080136,6.574113e-8,0.01827817,0.0001916859,0.9681255,0.0004294733],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004114552,0.9924551,0.0001779707,0.000129183,0.005729753,0.0007452241,0.0002767954,0.00002613353,0.00004841018],"genre_scores_gemma":[0.001665076,0.9963577,0.0003060346,0.0000326957,0.0004019025,0.00001402792,0.001058518,0.00003656366,0.0001274326],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9355557,"threshold_uncertainty_score":0.9998999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03781385558341503,"score_gpt":0.3360649200647971,"score_spread":0.2982510644813821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}