{"id":"W3216179038","doi":"10.1016/j.cbpa.2021.102099","title":"New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance","year":2021,"lang":"en","type":"review","venue":"Current Opinion in Chemical Biology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Antibiotics; Bacteria; Potentiator; Gram-negative bacteria; Antibiotic resistance; Bacterial outer membrane; Microbiology; Membrane permeability; Biology; Chemistry; Membrane; Biochemistry; Pharmacology; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006292129,0.001009039,0.001544295,0.0008198907,0.0001526061,0.001100798,0.001029557,0.001239799,0.002657019],"category_scores_gemma":[0.0005205502,0.0002571917,0.0004319966,0.0008188948,0.0006104893,0.001517858,0.000635325,0.003287892,0.002054534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004688308,"about_ca_system_score_gemma":0.000541091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003267627,"about_ca_topic_score_gemma":0.0007413657,"domain_scores_codex":[0.99984,0.00002655805,0.00001607821,0.00002989535,0.00005976503,0.00002768831],"domain_scores_gemma":[0.9997924,0.0000850431,0.00003319633,0.000007876974,0.00004979498,0.00003164374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003105383,0.0001723858,0.0001082461,0.01011964,0.0001053954,0.0002115015,0.00004181116,0.0004254481,0.01167447,0.004690494,0.03291545,0.9392247],"study_design_scores_gemma":[0.0001664587,0.0004249917,0.0007808005,0.00171039,0.0001770751,0.001078498,0.00004060496,0.0002573496,0.003214564,0.002315727,0.9897982,0.00003544594],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003214675,0.9975064,0.0003856573,0.000404758,0.0005395187,0.000009600148,0.00002322962,0.00001612711,0.0007932464],"genre_scores_gemma":[0.001793484,0.9957372,0.0004348562,0.0005558017,0.0004417794,0.00001733777,0.00006005884,0.000004333732,0.0009551844],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002657019,"threshold_uncertainty_score":0.008888662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03781385558341503,"score_gpt":0.3360649200647971,"score_spread":0.2982510644813821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}