{"id":"W3216189616","doi":"10.3389/fimmu.2021.772304","title":"O-GlcNAcylation in Chronic Lymphocytic Leukemia and Other Blood Cancers","year":2021,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; Leukemia and Lymphoma Society of Canada; Leukemia and Lymphoma Society","keywords":"Chronic lymphocytic leukemia; Cancer research; Glycosyltransferase; Serine; Biology; Cancer; Cancer cell; Signal transduction; Kinase; Tumor progression; Tumor microenvironment; Proteasome; Phosphorylation; Leukemia; Cell biology; Biochemistry; Gene; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001810654,0.0002794293,0.0002305146,0.0007145311,0.0002660161,0.0004709819,0.0001588754,0.0003338289,0.001535633],"category_scores_gemma":[0.0001745661,0.00006578423,0.0002076307,0.001146736,0.0002804997,0.0002479628,0.0002991249,0.0004595584,0.000584843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005247409,"about_ca_system_score_gemma":0.0003974805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001833373,"about_ca_topic_score_gemma":0.002009378,"domain_scores_codex":[0.9999224,0.00001175583,0.000009301665,0.00001472252,0.00002538128,0.00001641398],"domain_scores_gemma":[0.9999171,0.000006829908,0.00003147909,0.000004843347,0.00001591941,0.00002369007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002334552,0.0002827889,0.06319981,0.004705075,0.0002483066,0.005799925,0.0005196048,0.0006144316,0.2073899,0.007354068,0.03623148,0.6713201],"study_design_scores_gemma":[0.0001226269,0.0005716036,0.1692296,0.0007025287,0.0002955981,0.01856472,0.0004488713,0.0005809853,0.03354419,0.005957161,0.7699184,0.0000635701],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1629722,0.8086594,0.001791428,0.003850636,0.0008105231,0.00005732995,0.001249722,0.0001703279,0.02043852],"genre_scores_gemma":[0.5619774,0.4208574,0.001663041,0.001650118,0.001139207,0.0000490416,0.002125199,0.00002287424,0.01051562],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001833373,"threshold_uncertainty_score":0.005137146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01754042157148813,"score_gpt":0.3029612840529189,"score_spread":0.2854208624814308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}