{"id":"W3216246920","doi":"10.3390/ijms222312628","title":"BRCA Mutations in Prostate Cancer: Assessment, Implications and Treatment Considerations","year":2021,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"","keywords":"Prostate cancer; Carcinogenesis; Germline; Synthetic lethality; Germline mutation; Cancer; Cancer research; DNA repair; Biology; Somatic cell; Poly ADP ribose polymerase; DNA damage; Prostate; PARP inhibitor; Chromoplexy; Mutation; Genome instability; Genetics; Medicine; Gene; Polymerase; DNA; PCA3","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003044489,0.000177485,0.0006803725,0.000624952,0.00008199978,0.0001559842,0.0001538331,0.00005964722,0.0001234646],"category_scores_gemma":[0.00008199465,0.0001369821,0.0002502015,0.0003611142,0.0002417355,0.0001616454,0.00003094116,0.000214777,0.000001326156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000642845,"about_ca_system_score_gemma":0.004115536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004161141,"about_ca_topic_score_gemma":0.00004030652,"domain_scores_codex":[0.9982478,0.0001368136,0.000760167,0.0002483216,0.0004758652,0.000131007],"domain_scores_gemma":[0.9983873,0.0002177743,0.0006323754,0.0001133806,0.0005502741,0.00009888213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000007318278,0.0003634919,0.001176356,0.0001956059,0.000911981,0.000949517,0.0003200871,0.0001922928,0.0002188474,0.009101165,0.0002587725,0.9863046],"study_design_scores_gemma":[0.002983042,0.0006770135,0.001157697,0.01983687,0.001164348,0.01122052,0.0003204615,0.00005653559,0.0002110723,0.004037987,0.9578897,0.0004447158],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001074319,0.9920034,0.0002051705,0.005155034,0.0004056187,0.0003651072,0.000107329,0.000006013417,0.0006780157],"genre_scores_gemma":[0.004114228,0.991057,0.004198202,0.0002827529,0.000127837,0.0001190335,0.00003469253,0.00001292067,0.00005328101],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9858599,"threshold_uncertainty_score":0.7300783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09424596685189343,"score_gpt":0.485535620611989,"score_spread":0.3912896537600956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}