{"id":"W3216268272","doi":"10.1182/blood-2021-152407","title":"Real-World Data on the Occurrence of Vaso-Occlusive Crises (VOCs) in Patients with Sickle Cell Disease (SCD) and a High Baseline Disease Burden Treated with Crizanlizumab: Results from a Managed Access Program (MAP)","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Vaso-occlusive crisis; Disease; Clinical trial; Disease burden; Disease registry; Internal medicine; Pediatrics; Sickle cell anemia","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002734126,0.0002483198,0.0005108684,0.001167064,0.0003009235,0.001117251,0.0004528966,0.000600705,0.001796363],"category_scores_gemma":[0.01124022,0.0002086381,0.0008298015,0.002461127,0.0002550485,0.000784435,0.0008180073,0.0008408629,0.0003728216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000771585,"about_ca_system_score_gemma":0.0007207268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00590516,"about_ca_topic_score_gemma":0.00352231,"domain_scores_codex":[0.996011,0.0015635,0.0007091056,0.0006881978,0.0007383989,0.0002897688],"domain_scores_gemma":[0.9839642,0.003270302,0.009364839,0.0006135792,0.001685181,0.001101884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001271317,0.0001082156,0.990928,0.0001959662,0.0003381559,0.00006441287,0.0001510134,0.0002269219,0.00009132616,0.00006223302,0.002250943,0.004311553],"study_design_scores_gemma":[0.0001365055,0.0004575583,0.9960182,0.00009915541,0.0001824634,0.0002435428,0.0003407192,0.0006880561,0.00009489081,0.00006084583,0.001659831,0.00001809737],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697133,0.00136884,0.000374507,0.0004064915,0.00002189224,0.00008017108,0.02639079,0.00002341892,0.001620554],"genre_scores_gemma":[0.9833043,0.0004408525,0.0003822346,0.0001700754,0.00003978959,0.0001454374,0.01530451,0.000008233441,0.0002046866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00590516,"threshold_uncertainty_score":0.01445961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01828882229258874,"score_gpt":0.2681212378698501,"score_spread":0.2498324155772614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}