{"id":"W3216334861","doi":"10.1093/neuonc/noab196.032","title":"EPCO-33. CELL-TYPE PROPORTION DECONVOLUTION OF PEDIATRIC CENTRAL NERVOUS SYSTEM TUMORS FROM SINGLE NUCLEI RNA-seq UNCOVERS UNDERLYING TRANSCRIPTOMIC CHANGES FROM BULK TUMOR RNA-seq COMPARED TO NORMAL BRAIN","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Biology; Transcriptome; Gene; RNA; Cell type; RNA-Seq; Gene expression; Brain tumor; Cell; Molecular biology; Cancer research; Genetics; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003898593,0.0003376358,0.0003220663,0.0005205736,0.0003817764,0.0005256863,0.0003346048,0.0003095238,0.005040062],"category_scores_gemma":[0.0005944014,0.0002918772,0.0003177838,0.0004274808,0.0001966585,0.0001936798,0.000392139,0.0004248121,0.001589479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005010952,"about_ca_system_score_gemma":0.0004755954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00465051,"about_ca_topic_score_gemma":0.01007824,"domain_scores_codex":[0.999721,0.00001780427,0.00001271378,0.0001156799,0.00009347688,0.00003936621],"domain_scores_gemma":[0.9997042,0.00008616253,0.00005035492,0.00003322859,0.00008423603,0.0000417285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004959832,0.00003378151,0.02218182,0.0001948903,0.00006124268,0.0001550619,0.0001141144,0.001506074,0.9509401,0.0003587479,0.004440194,0.01951796],"study_design_scores_gemma":[0.00008017412,0.0002844621,0.2665963,0.00006075564,0.0001260424,0.0009869389,0.0002144121,0.03319107,0.6688312,0.0005181056,0.0290633,0.00004723394],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9007567,0.0008386243,0.03875475,0.0002284784,0.00007271822,0.0001582379,0.0510483,0.00285954,0.005282725],"genre_scores_gemma":[0.8548518,0.000558854,0.04829473,0.0002898363,0.00001954141,0.000558992,0.08749758,0.00139436,0.006534379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005040062,"threshold_uncertainty_score":0.01686066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.037818530060769,"score_gpt":0.272793617414925,"score_spread":0.234975087354156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}