{"id":"W3216374640","doi":"10.1126/sciadv.abj1826","title":"Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"University of California, San Francisco; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Università degli Studi di Trento; Werner Otto Stiftung; Deutsche Forschungsgemeinschaft; Ludwig-Maximilians-Universität München; Alzheimer Forschung Initiative","keywords":"Prion protein; Protein aggregation; Chemistry; Cell biology; Proteolysis; Biology; Biochemistry; Medicine; Disease; Enzyme; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003856289,0.0001560343,0.0001094964,0.00007940154,0.0003703701,0.000139265,0.0003888477,0.00004000264,0.000007162373],"category_scores_gemma":[0.0002645583,0.000103402,0.00003369294,0.0009170346,0.0001851355,0.00005275605,0.0001847984,0.0001311088,0.000008320339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002576672,"about_ca_system_score_gemma":0.0005524648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005467963,"about_ca_topic_score_gemma":0.00006586098,"domain_scores_codex":[0.9984305,0.00007574145,0.0001606212,0.0005970543,0.0003626704,0.0003734082],"domain_scores_gemma":[0.9992868,0.000005593636,0.00008018415,0.0003373516,0.0001789646,0.0001111502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001013338,0.0000341236,0.0003034469,0.00001822612,0.000003494732,0.00002026764,0.0001043275,0.001493041,0.9639398,0.00007048633,0.000002327417,0.03390909],"study_design_scores_gemma":[0.0002434868,0.0003363894,0.0009220224,0.0001007517,0.000005056749,0.00001299077,0.0002789588,0.0001071673,0.9961458,0.0001023505,0.001565948,0.0001790125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886136,0.007657482,0.0009725603,0.001437972,0.00007708564,0.001186274,0.000005426343,0.00001184926,0.00003773138],"genre_scores_gemma":[0.997845,0.0001968577,0.0008700463,0.000376218,0.0001081885,0.0003939115,0.000004226687,0.00001285852,0.0001927074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03373008,"threshold_uncertainty_score":0.421661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009440602745940743,"score_gpt":0.2600759358271291,"score_spread":0.2506353330811883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}