{"id":"W3216374640","doi":"10.1126/sciadv.abj1826","title":"Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"University of California, San Francisco; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Università degli Studi di Trento; Werner Otto Stiftung; Deutsche Forschungsgemeinschaft; Ludwig-Maximilians-Universität München; Alzheimer Forschung Initiative","keywords":"Prion protein; Protein aggregation; Chemistry; Cell biology; Proteolysis; Biology; Biochemistry; Medicine; Disease; Enzyme; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003423325,0.000433958,0.0003705242,0.0002284389,0.0002117603,0.0004295709,0.0001827524,0.0005060997,0.002121096],"category_scores_gemma":[0.0002659008,0.000122339,0.0002251268,0.0001123914,0.0003490096,0.000286262,0.0002739707,0.0007265651,0.0006755344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001638242,"about_ca_system_score_gemma":0.0001715531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001145345,"about_ca_topic_score_gemma":0.0002748037,"domain_scores_codex":[0.9998423,0.00006677142,0.000009823822,0.00001762922,0.0000327537,0.00003073189],"domain_scores_gemma":[0.9998832,0.00003087719,0.00002922496,0.0000142949,0.00001420914,0.00002820918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003654229,0.0001358371,0.0002636343,0.0001974775,0.0000185049,0.0005558351,0.00004938415,0.0002294973,0.9806874,0.001428976,0.0004118383,0.01565615],"study_design_scores_gemma":[0.0002155416,0.003485124,0.005419503,0.00007186224,0.00006222569,0.003732285,0.00009311956,0.00122859,0.9644133,0.001550936,0.01969923,0.0000282462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9092978,0.04274455,0.02738651,0.001339707,0.0005231664,0.0004192524,0.0004044889,0.0005971708,0.01728749],"genre_scores_gemma":[0.9861658,0.005376082,0.004258567,0.0002457237,0.00008403774,0.00008702266,0.0001957793,0.00003538376,0.003551559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002121096,"threshold_uncertainty_score":0.007095754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009440602745940743,"score_gpt":0.2600759358271291,"score_spread":0.2506353330811883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}