{"id":"W3216388079","doi":"10.21037/atm-21-6102","title":"A multicenter single-arm trial of sintilimab in combination with chemotherapy for neoadjuvant treatment of resectable esophageal cancer (SIN-ICE study)","year":2021,"lang":"en","type":"article","venue":"Annals of Translational Medicine","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Fourth Military Medical University; National Natural Science Foundation of China","keywords":"Medicine; Neoadjuvant therapy; Esophageal cancer; Leukopenia; Chemotherapy; Surgery; Clinical endpoint; Rash; Neutropenia; Vomiting; Internal medicine; Esophagectomy; Dysphagia; Clinical trial; Oncology; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002667215,0.0001613543,0.0007110973,0.0002104326,0.00002279917,0.000002225438,0.00005076741,0.00004816076,0.0002008835],"category_scores_gemma":[0.00007093053,0.0001118304,0.0001119902,0.0003645618,0.0001381931,0.00006733381,0.000003893943,0.00005961011,1.793388e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000609866,"about_ca_system_score_gemma":0.0003783178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008226182,"about_ca_topic_score_gemma":0.0007311457,"domain_scores_codex":[0.9981835,0.00007417452,0.0005957222,0.000257703,0.0006763489,0.0002125916],"domain_scores_gemma":[0.9983661,0.0003334238,0.0001931262,0.0001981465,0.0008182279,0.00009097245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.596651,0.09733679,0.146688,0.001568771,0.00291784,0.0002927014,0.0112163,0.000385014,0.01687218,0.0005205821,0.0002004254,0.1253504],"study_design_scores_gemma":[0.5001439,0.1135539,0.1536269,0.001253197,0.0004241237,0.000008202097,0.0007797158,0.000638003,0.2287146,0.0004031315,0.0003127694,0.0001415906],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742943,0.009565631,0.0001613281,0.01282593,0.00007161195,0.002751566,0.00009183501,0.000006858391,0.00023092],"genre_scores_gemma":[0.9979,0.0006539985,0.0007124912,0.00009870824,0.0001002098,0.0002075945,0.0001273809,0.00001932683,0.0001803059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2118424,"threshold_uncertainty_score":0.456031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1085002797298619,"score_gpt":0.4149310850748604,"score_spread":0.3064308053449986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}