{"id":"W3216398121","doi":"10.3390/biomedicines9121807","title":"Shiga Toxin 2a Induces NETosis via NOX-Dependent Pathway","year":2021,"lang":"en","type":"article","venue":"Biomedicines","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Neutrophil extracellular traps; Thrombotic microangiopathy; Pathogenesis; Biology; Shiga toxin; Microbiology; Escherichia coli; Immunology; Inflammation; Disease; Medicine; Gene; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000194995,0.0002610668,0.0003951834,0.0001623978,0.0001867951,0.00001875286,0.0002427515,0.0002667186,0.002252873],"category_scores_gemma":[0.00006263039,0.0002006514,0.00009606624,0.0003591237,0.0002039311,0.00009518908,0.0001573535,0.0002532939,0.001205014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003434875,"about_ca_system_score_gemma":0.0001021936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008408775,"about_ca_topic_score_gemma":0.00004206865,"domain_scores_codex":[0.9984811,0.0001861202,0.0003389699,0.0004809448,0.0000831804,0.0004296611],"domain_scores_gemma":[0.9992098,0.00009672121,0.0001028223,0.0003894576,0.000144593,0.00005655541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003322802,0.0001371294,0.0002114458,0.0000184991,0.0001462286,0.0001279694,0.0002391095,1.327906e-7,0.9782457,0.0008045411,0.002719878,0.01731609],"study_design_scores_gemma":[0.001034289,0.0002239674,0.00151811,0.00005761655,0.000046036,0.0001565232,0.0005217017,3.892218e-7,0.8979076,0.0003894349,0.09792293,0.0002214772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844665,0.007043244,0.0006967335,0.002844103,0.002855698,0.0001816568,0.00005722399,0.0001378763,0.001716978],"genre_scores_gemma":[0.9887806,0.0002456555,0.0001638986,0.001868352,0.0003136859,0.00003324576,0.0002682084,0.00002698638,0.008299347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09520305,"threshold_uncertainty_score":0.9995726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01807632069947041,"score_gpt":0.2354594975843086,"score_spread":0.2173831768848382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}