{"id":"W3216407054","doi":"10.1080/1744666x.2022.2008240","title":"TYK2 inhibition: changing the treatment landscape for psoriasis?","year":2021,"lang":"en","type":"article","venue":"Expert Review of Clinical Immunology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research; Queen's University; SKiN Health; Western University","funders":"","keywords":"Disease; Perspective (graphical); Immune system; MEDLINE; Insulin degludec","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002112962,0.0006647501,0.00204085,0.0007112351,0.0003165826,0.002325749,0.001156912,0.00206339,0.005240549],"category_scores_gemma":[0.002100528,0.0002353267,0.001050048,0.000628218,0.0008947017,0.002327977,0.0009277849,0.007301205,0.002073638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008158498,"about_ca_system_score_gemma":0.001381254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008267975,"about_ca_topic_score_gemma":0.002638791,"domain_scores_codex":[0.9994507,0.000153,0.00006238056,0.00009072181,0.0001515658,0.00009156459],"domain_scores_gemma":[0.9988022,0.0005351104,0.0001561974,0.00003170457,0.0003033076,0.0001715573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000848,0.0001865089,0.0004412305,0.005351499,0.0002513372,0.0001874455,0.00005762604,0.0003941057,0.002961735,0.006026977,0.1130765,0.870217],"study_design_scores_gemma":[0.000731857,0.0008225975,0.001416207,0.005113367,0.0003880755,0.0007511291,0.000166379,0.0004571091,0.0009917627,0.008980909,0.9801211,0.00005951609],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004662559,0.9822374,0.0003353865,0.01335113,0.002321834,0.00001028108,0.00004590107,0.00003852267,0.001193282],"genre_scores_gemma":[0.007103646,0.9736067,0.0008372871,0.01163536,0.004758059,0.00003109528,0.0001184856,0.0000167479,0.001892525],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005240549,"threshold_uncertainty_score":0.01753139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06068640059237729,"score_gpt":0.3793582426775274,"score_spread":0.3186718420851501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}