{"id":"W3216431394","doi":"10.1128/mbio.02557-21","title":"Herpes Simplex Virus Type 1 Infection Disturbs the Mitochondrial Network, Leading to Type I Interferon Production through the RNA Polymerase III/RIG-I Pathway","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ligue Contre le Cancer; Institut Pasteur; University of Alberta","keywords":"Mitochondrial DNA; Interferon; Polymerase; Mitochondrion; Herpes simplex virus; RNA; DNA; Human mitochondrial genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001288578,0.000192268,0.0002175234,0.00002976681,0.0004799449,0.00008036762,0.00006650837,0.00009508913,0.0003424438],"category_scores_gemma":[0.0001892194,0.0001119003,0.0001027798,0.0007378901,0.0000655321,0.0001102375,0.00007465709,0.0002381946,0.000382591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001627333,"about_ca_system_score_gemma":0.0001226696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001597836,"about_ca_topic_score_gemma":0.002023774,"domain_scores_codex":[0.9987718,0.0001469295,0.0002411524,0.0003518746,0.0001842144,0.0003040222],"domain_scores_gemma":[0.999102,0.00006723473,0.00006787763,0.0005232684,0.0001671191,0.00007250223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002396467,0.001588299,0.004625036,0.00007273698,0.001317832,0.0001352318,0.005976743,0.0008553953,0.05474832,0.001239637,0.1060608,0.8209835],"study_design_scores_gemma":[0.0007634778,0.0005088038,0.002647342,0.0001023757,0.0002086862,0.00007806148,0.0001538868,0.00002552388,0.08836231,0.0002772976,0.9066995,0.0001726929],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818959,0.0007360617,0.0007206214,0.003871343,0.006830738,0.0007594511,0.000007112089,0.0001300149,0.005048796],"genre_scores_gemma":[0.9880884,0.0001355319,0.0001670776,0.001071013,0.002589812,0.00005188531,0.00005212884,0.00003335019,0.007810827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8208108,"threshold_uncertainty_score":0.4917561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03393860972029859,"score_gpt":0.308313876622106,"score_spread":0.2743752669018074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}