{"id":"W3216431394","doi":"10.1128/mbio.02557-21","title":"Herpes Simplex Virus Type 1 Infection Disturbs the Mitochondrial Network, Leading to Type I Interferon Production through the RNA Polymerase III/RIG-I Pathway","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ligue Contre le Cancer; Institut Pasteur; University of Alberta","keywords":"Mitochondrial DNA; Interferon; Polymerase; Mitochondrion; Herpes simplex virus; RNA; DNA; Human mitochondrial genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018636,0.0003244993,0.0002066696,0.0001868306,0.0002357149,0.000491031,0.000138504,0.0002695328,0.001440516],"category_scores_gemma":[0.0001593389,0.00007408331,0.0002941489,0.0001315061,0.0002518804,0.000260051,0.0002318639,0.0006996918,0.0001970196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004451989,"about_ca_system_score_gemma":0.0003281882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008171441,"about_ca_topic_score_gemma":0.001173172,"domain_scores_codex":[0.9998243,0.00004670377,0.00001277181,0.00002899361,0.00003611646,0.00005115765],"domain_scores_gemma":[0.999927,0.00001315309,0.00002262648,0.00001392591,0.00001096137,0.00001230436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002760321,0.00004925202,0.001175964,0.0001607439,0.00002865198,0.0001222166,0.00005538171,0.0001291434,0.9918517,0.0007377876,0.0001274594,0.005285623],"study_design_scores_gemma":[0.0000236258,0.0005847366,0.008363797,0.00003813718,0.00005397704,0.0006231804,0.0001488686,0.001253644,0.9825814,0.000567327,0.005750963,0.0000102546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9606925,0.02101612,0.01081651,0.0006026269,0.0002526835,0.00009089521,0.0008185782,0.0001198942,0.005590215],"genre_scores_gemma":[0.9942048,0.0029794,0.001641079,0.00005233118,0.00001774745,0.00002859423,0.0002194179,0.000005059225,0.0008515979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001440516,"threshold_uncertainty_score":0.004819036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03393860972029859,"score_gpt":0.308313876622106,"score_spread":0.2743752669018074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}