{"id":"W3216478751","doi":"10.1038/s41586-021-04266-9","title":"Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation","year":2021,"lang":"en","type":"article","venue":"Nature","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":681,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Daiichi Sankyo Europe; Strategic International Collaborative Research Program; Core Research for Evolutional Science and Technology; Research Institute for Microbial Diseases, Osaka University; Lotte Foundation; Institute of Genetics; National Institutes of Health; Daiichi Sankyo Foundation of Life Science; Ono Medical Research Foundation; Japan Society for the Promotion of Science; Mochida Memorial Foundation for Medical and Pharmaceutical Research; Tsuchiya Foundation; Takeda Science Foundation; Mitsubishi Foundation; Sumitomo Foundation; Tokyo Biochemical Research Foundation; University of Tokyo; Japan Agency for Medical Research and Development; National Institute of Allergy and Infectious Diseases; Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care","keywords":"Pathogenicity; Mutation; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Biology; Virology; Genetics; Medicine; Microbiology; Disease; Gene; Infectious disease (medical specialty); Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001079616,0.0002437791,0.0001769264,0.0002032816,0.0001253845,0.0001281904,0.000101563,0.0002564093,0.000925719],"category_scores_gemma":[0.0001405739,0.00006032297,0.0002020599,0.000101693,0.0001440674,0.0001160663,0.000157135,0.0002711492,0.0001871157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000154846,"about_ca_system_score_gemma":0.00007624245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006315431,"about_ca_topic_score_gemma":0.0003616752,"domain_scores_codex":[0.9998773,0.0000299976,0.00001094038,0.00001701013,0.00004057487,0.00002416903],"domain_scores_gemma":[0.9999108,0.0000208806,0.00002784729,0.000009553519,0.00001172439,0.00001920339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009515946,0.00002421842,0.0006369408,0.00001144137,0.000003308244,0.0002483178,0.00001199819,0.00003036398,0.9984885,0.00004288396,0.00002579326,0.0003810248],"study_design_scores_gemma":[0.00002844732,0.001851341,0.03157372,0.000008631692,0.00002424344,0.003847718,0.00009194915,0.001733442,0.9594943,0.000107342,0.001226637,0.00001220367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990301,0.0002244531,0.00020771,0.00002282498,0.00001057475,0.000006681221,0.0001120283,0.00001009207,0.0003755346],"genre_scores_gemma":[0.9992216,0.00009706283,0.0001957101,0.00001688017,0.000004866925,0.000003788855,0.0001630748,0.000002262131,0.0002947734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000925719,"threshold_uncertainty_score":0.003096819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02917837836519013,"score_gpt":0.3576371664179229,"score_spread":0.3284587880527328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}