{"id":"W3216493769","doi":"10.3390/jpm11111233","title":"Association between Genetic Variants and Cisplatin-Induced Nephrotoxicity: A Genome-Wide Approach and Validation Study","year":2021,"lang":"en","type":"article","venue":"Journal of Personalized Medicine","topic":"Chemotherapy-induced organ toxicity mitigation","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University Health Network; Princess Margaret Cancer Centre; BC Children's Hospital; University of Toronto","funders":"Lembaga Pengelola Dana Pendidikan","keywords":"Genome-wide association study; Minor allele frequency; Single-nucleotide polymorphism; Cohort; Medicine; 1000 Genomes Project; Genotyping; Renal function; Oncology; Internal medicine; Bioinformatics; Kidney disease; Genotype; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001429577,0.0002277722,0.0008656848,0.0002717003,0.000109619,0.00003876294,0.00006508052,0.0001782257,0.0001764041],"category_scores_gemma":[0.001515833,0.0001905376,0.0000768251,0.000409765,0.00006584921,0.000167097,0.00003439352,0.0004824175,0.000001518438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003254834,"about_ca_system_score_gemma":0.0002453863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002456809,"about_ca_topic_score_gemma":0.000003976883,"domain_scores_codex":[0.9973779,0.0002824956,0.0008055476,0.0003067412,0.0009928138,0.0002345266],"domain_scores_gemma":[0.9977407,0.0003809925,0.0007792452,0.0001806018,0.000595974,0.0003224981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002275679,0.0003848037,0.4294182,0.000166246,0.001156036,0.0001615913,0.01054384,0.000001287155,0.5538538,0.000006371114,0.0002708537,0.003809411],"study_design_scores_gemma":[0.0174873,0.002014563,0.948834,0.0002952743,0.00206815,0.0009928417,0.005999724,0.0001125955,0.02150332,0.0002139166,0.0002641559,0.0002141539],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910293,0.0008365774,0.001713114,0.005505204,0.00009485974,0.0006034389,0.000003803489,0.00001708318,0.0001966762],"genre_scores_gemma":[0.9925418,0.0003090236,0.004734404,0.0008283687,0.001094383,0.000005881802,0.00002379019,0.00003794049,0.0004244389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5323504,"threshold_uncertainty_score":0.7769896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03337728142155385,"score_gpt":0.2947569951709378,"score_spread":0.261379713749384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}