{"id":"W3216496143","doi":"10.1021/jacs.1c10200","title":"Prospects for Antibacterial Discovery and Development","year":2021,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Division of Graduate Education; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Canada Research Chairs","keywords":"Druggability; Panacea (medicine); Drug discovery; Antibiotic resistance; Drug development; Antibiotics; Computational biology; Data science; Business; Biotechnology; Chemistry; Risk analysis (engineering); Computer science; Biology; Drug; Medicine; Bioinformatics; Pharmacology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01095367,0.001288581,0.001245603,0.0014165,0.001535906,0.005677424,0.001834393,0.009670641,0.02855481],"category_scores_gemma":[0.00714356,0.0004762198,0.001328282,0.0009618541,0.005234457,0.01240138,0.003243145,0.008776926,0.01265997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002731149,"about_ca_system_score_gemma":0.007057852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007189398,"about_ca_topic_score_gemma":0.0009700509,"domain_scores_codex":[0.9972162,0.0009034525,0.0001841536,0.0004044015,0.0008169286,0.0004748288],"domain_scores_gemma":[0.9937471,0.002607819,0.0004484725,0.0005157673,0.001350331,0.001330458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004418099,0.000454215,0.0006923485,0.002035208,0.00006101755,0.000395809,0.000245347,0.001446185,0.005141605,0.4935118,0.1858218,0.3097528],"study_design_scores_gemma":[0.00007304376,0.0003915604,0.0003430138,0.0007273752,0.00003244817,0.000227778,0.0002890625,0.0008813382,0.001037798,0.1993645,0.7965935,0.00003863575],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00306796,0.5897867,0.02455996,0.2963162,0.01928497,0.0001199314,0.0004791071,0.0005150805,0.06586998],"genre_scores_gemma":[0.07922363,0.7196313,0.04258683,0.08999258,0.02280146,0.0006848355,0.001261131,0.000167715,0.0436505],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02855481,"threshold_uncertainty_score":0.09552532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124990146669055,"score_gpt":0.2485887313615676,"score_spread":0.237338829894877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}