{"id":"W3216507911","doi":"10.3390/molecules26237218","title":"Transporter Protein-Guided Genome Mining for Head-to-Tail Cyclized Bacteriocins","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Mount Royal University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bacteriocin; Genome; Gene; Biology; Computational biology; Antimicrobial peptides; Whole genome sequencing; Peptide; Genetics; Biochemistry; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001553948,0.0002079416,0.0002313848,0.00003858063,0.0001073043,0.00004761648,0.0001908848,0.000160376,0.0001017201],"category_scores_gemma":[0.00009659997,0.0002093104,0.0001976907,0.00008699277,0.00002446654,0.000003350119,0.00005037612,0.00003972197,0.00001835667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001127789,"about_ca_system_score_gemma":0.0001025146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005832033,"about_ca_topic_score_gemma":0.00003530357,"domain_scores_codex":[0.998667,0.00006544174,0.0002714224,0.0005145905,0.0001245471,0.0003569863],"domain_scores_gemma":[0.9992484,0.000009456313,0.00006143639,0.0004163534,0.0001233292,0.0001410245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001096456,0.00004145744,0.00004210021,0.00003817987,0.00005862854,0.00002006527,0.00009219596,0.00001352546,0.9962339,0.0001123538,0.0001872588,0.003050634],"study_design_scores_gemma":[0.0005878423,0.0001970577,0.0006215165,0.00003303163,0.00002334439,0.00001553262,0.0000589905,0.000006912916,0.8951387,0.0001319614,0.1029185,0.0002665881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.924776,0.0004159401,0.07233975,0.0009112257,0.00009361119,0.0006453571,0.00007283988,0.00002458621,0.0007207076],"genre_scores_gemma":[0.9294983,0.00002825853,0.06399489,0.001367657,0.0002343989,0.0005025528,0.0003366563,0.00007005849,0.003967288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1027312,"threshold_uncertainty_score":0.853543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02289402713824994,"score_gpt":0.2667357338235949,"score_spread":0.2438417066853449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}