{"id":"W3216562266","doi":"10.3389/fphar.2021.746420","title":"Pulsatile Bi-Directional Aerosol Flow Affects Aerosol Delivery to the Intranasal Olfactory Region: A Patient-Specific Computational Study","year":2021,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Deutsche Forschungsgemeinschaft","keywords":"Nasal cavity; Olfactory epithelium; Nasal administration; Nostril; Aerosol; Pulsatile flow; Nose; Particle deposition; Olfactory system; Biomedical engineering; Medicine; Chemistry; Anatomy; Internal medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002333625,0.0002180933,0.0003715491,0.0002878802,0.0003338883,0.00002279347,0.0001473422,0.0001010596,0.001843699],"category_scores_gemma":[0.00002857132,0.0001896395,0.0001221894,0.0006477102,0.0001161653,0.00009172059,0.0001193426,0.0005682535,0.0000472029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003934025,"about_ca_system_score_gemma":0.0003810489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005773086,"about_ca_topic_score_gemma":0.00001572419,"domain_scores_codex":[0.9976023,0.0006790787,0.0003861316,0.0005013621,0.0004685805,0.0003625139],"domain_scores_gemma":[0.9991435,0.0001579785,0.00009891639,0.0002126071,0.0002119171,0.0001750133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001374765,0.001813131,0.02087116,0.00002778649,0.0003558371,0.001671388,0.003721236,0.05225145,0.002873148,0.00000757869,0.8933458,0.02168672],"study_design_scores_gemma":[0.03948097,0.005331321,0.05244749,0.0001389779,0.000836182,0.001628604,0.02902757,0.08532937,0.02958063,0.00006470333,0.7539548,0.002179364],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785323,0.001518612,0.004618352,0.003460692,0.009349765,0.001694802,0.00003357781,0.00008852323,0.0007033696],"genre_scores_gemma":[0.9883852,0.00007649512,0.002146141,0.007863178,0.0006053906,0.0002817989,0.00009281921,0.00003385617,0.0005151365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.139391,"threshold_uncertainty_score":0.9990687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02334075804655346,"score_gpt":0.2712969817311003,"score_spread":0.2479562236845469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}