{"id":"W3216581958","doi":"10.1182/blood-2021-145954","title":"Population-Wide Introduction of Dose-Adjusted EPOCH-R Is Associated with Improved Outcome of High Grade B-Cell Lymphoma with MYC and BCL2 Rearrangements with Diffuse Large B-Cell Lymphoma Morphology","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Spinal Cord Injury BC; University of British Columbia","funders":"","keywords":"Diffuse large B-cell lymphoma; Vincristine; Medicine; Rituximab; Population; Internal medicine; Epoch (astronomy); BCL6; Lymphoma; Prednisone; Oncology; Cyclophosphamide; Chemotherapy; Immunology; B cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006656671,0.0001410799,0.0002676106,0.0001569665,0.0001747134,0.0005482876,0.0003413373,0.0002974535,0.001340362],"category_scores_gemma":[0.001425041,0.0001092018,0.0003879078,0.0005013938,0.0002122181,0.0002843289,0.0002681472,0.0006552216,0.0002473517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004494652,"about_ca_system_score_gemma":0.0004668943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004126783,"about_ca_topic_score_gemma":0.005352935,"domain_scores_codex":[0.9995504,0.0001405378,0.00003282371,0.0001611104,0.00005667989,0.00005847933],"domain_scores_gemma":[0.9991093,0.0001129023,0.0003213825,0.0001452913,0.0001395272,0.0001716449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003981222,0.0001630413,0.9411617,0.00006149989,0.0008221406,0.000195507,0.00009533697,0.000589787,0.005400061,0.0001473343,0.002140559,0.04524179],"study_design_scores_gemma":[0.000103085,0.0006794806,0.9935001,0.00001581244,0.000480859,0.0003719045,0.00008115765,0.0004846789,0.0007056252,0.0001170668,0.003451128,0.000009161382],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946944,0.00210143,0.0004885645,0.0003453574,0.00004082342,0.0000152665,0.0007007186,0.00006711375,0.001546334],"genre_scores_gemma":[0.9985362,0.0002855191,0.0001523018,0.0001876991,0.0000189235,0.000006904461,0.0004593949,0.0000132261,0.0003397362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004126783,"threshold_uncertainty_score":0.008205533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01071754212375003,"score_gpt":0.2224572612275381,"score_spread":0.2117397191037881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}