{"id":"W3216624362","doi":"10.1182/blood-2021-147333","title":"Clinical Activity of CC-99282, a Novel, Oral Small Molecule Cereblon E3 Ligase Modulator (CELMoD) Agent, in Patients (Pts) with Relapsed or Refractory Non-Hodgkin Lymphoma (R/R NHL) - First Results from a Phase 1, Open-Label Study","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Lenalidomide; Tolerability; Internal medicine; Lymphoma; Follicular lymphoma; Cereblon; Oncology; Pharmacology; Adverse effect; Multiple myeloma; Biology; Ubiquitin ligase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004214789,0.0003259803,0.0005353388,0.00006798538,0.00008772095,0.00006022285,0.0004574291,0.0002957284,0.00001348978],"category_scores_gemma":[0.0006801897,0.0002806328,0.00008871761,0.0003095178,0.00008727658,0.00002769932,0.0005135798,0.0001941759,0.000005308277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003819758,"about_ca_system_score_gemma":0.0004468218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007094273,"about_ca_topic_score_gemma":0.002156404,"domain_scores_codex":[0.9972839,0.0002801589,0.0007962813,0.001020292,0.0002981113,0.0003212864],"domain_scores_gemma":[0.998,0.0000624622,0.0004755274,0.001026492,0.0002345468,0.0002009374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"nonrandomized_trial","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02875565,0.5225531,0.03040786,0.00006373217,0.0009290899,0.0003370869,0.000424132,0.000008683762,0.4010552,0.000003379034,0.001208767,0.01425328],"study_design_scores_gemma":[0.3097621,0.01000171,0.02690541,0.0001430784,0.0001583923,0.000004905498,0.0001070348,0.0002374212,0.6505143,0.000002383434,0.001666208,0.000497119],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977669,0.00005721566,0.0001398902,0.00005037681,0.0001420763,0.001093523,0.0005425206,0.00001481565,0.0001926814],"genre_scores_gemma":[0.9963489,0.00003804095,0.002283121,0.0001390121,0.00009485552,0.00007982422,0.0006709169,0.00005236285,0.0002929833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5125514,"threshold_uncertainty_score":0.9999646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0472277822596604,"score_gpt":0.3196736704764509,"score_spread":0.2724458882167905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}