{"id":"W3216624362","doi":"10.1182/blood-2021-147333","title":"Clinical Activity of CC-99282, a Novel, Oral Small Molecule Cereblon E3 Ligase Modulator (CELMoD) Agent, in Patients (Pts) with Relapsed or Refractory Non-Hodgkin Lymphoma (R/R NHL) - First Results from a Phase 1, Open-Label Study","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Lenalidomide; Tolerability; Internal medicine; Lymphoma; Follicular lymphoma; Cereblon; Oncology; Pharmacology; Adverse effect; Multiple myeloma; Biology; Ubiquitin ligase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006280973,0.0006679612,0.0009280271,0.0002562814,0.0001881315,0.0006339248,0.0004417245,0.0006821664,0.001520806],"category_scores_gemma":[0.0004490988,0.0002456682,0.0006047207,0.0002319822,0.0003994076,0.0004225739,0.0001580043,0.001415956,0.0004602443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006669473,"about_ca_system_score_gemma":0.0004981798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000578405,"about_ca_topic_score_gemma":0.001595927,"domain_scores_codex":[0.9998079,0.00007877018,0.00001254477,0.00003240074,0.00003183204,0.00003657854],"domain_scores_gemma":[0.9996459,0.00007678435,0.0000720955,0.00002890132,0.00003026626,0.0001460195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3358486,0.04933823,0.02423615,0.001545468,0.001816157,0.0009142008,0.0004612343,0.004863781,0.3284644,0.0003394678,0.006641217,0.2455311],"study_design_scores_gemma":[0.2301921,0.6483396,0.0663849,0.00007889579,0.001424436,0.001434796,0.0001735304,0.003468852,0.03570817,0.0002689495,0.01245109,0.00007466982],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939222,0.002664319,0.0003018499,0.0001819512,0.00003232891,0.0005342506,0.0008011558,0.00006764076,0.00149435],"genre_scores_gemma":[0.9938193,0.00153523,0.00063821,0.0004002895,0.00006975786,0.0003505612,0.002000739,0.00001993789,0.001165939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001520806,"threshold_uncertainty_score":0.005087614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0472277822596604,"score_gpt":0.3196736704764509,"score_spread":0.2724458882167905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}