{"id":"W3216647927","doi":"10.1016/j.cbi.2006.05.007","title":"Mitochondrial involvement in genetically determined transition metal toxicity","year":2006,"lang":"en","type":"review","venue":"Chemico-Biological Interactions","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Canada Research Chairs","funders":"","keywords":"Mitochondrion; Biology; Sideroblastic anemia; Aconitase; Cell biology; Frataxin; Cytosol; Ferritin; Biochemistry; Hemochromatosis; Oxidative stress; Mitochondrial toxicity; Genetics; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001022888,0.0005048958,0.001729917,0.0002488929,0.00005726002,0.00002744841,0.0001822681,0.0005814693,0.0007995796],"category_scores_gemma":[0.0001733382,0.0003611287,0.00089508,0.0003092378,0.0001595728,0.00006970205,0.00006098576,0.0008769683,0.0001268362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002220783,"about_ca_system_score_gemma":0.0001370775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004861396,"about_ca_topic_score_gemma":0.00004846896,"domain_scores_codex":[0.9975677,0.0001385082,0.001026052,0.0006666811,0.0001789418,0.0004221137],"domain_scores_gemma":[0.9989954,0.000213216,0.0002081507,0.000357072,0.00006192861,0.0001642435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004984858,0.005532066,0.00004421916,0.01121448,0.0003487041,0.0002807826,0.0001891069,0.000006071141,0.03439159,0.0003434256,0.009475387,0.9376757],"study_design_scores_gemma":[0.001083351,0.0001798352,0.00005035139,0.00177323,0.00104678,0.0001412903,0.00004215123,0.00001364141,0.0006803051,0.000114616,0.9944131,0.0004613228],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007010269,0.9847791,0.0004152262,0.0001319809,0.0009519988,0.001599667,0.0001413027,0.0001179302,0.004852576],"genre_scores_gemma":[0.0009339455,0.9928238,0.001396548,0.0003684696,0.000908236,0.0004668875,0.002441446,0.00004148662,0.0006191233],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9849377,"threshold_uncertainty_score":0.9998841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0735478924309209,"score_gpt":0.3548260638834383,"score_spread":0.2812781714525174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}