{"id":"W3216658736","doi":"10.1002/bdr2.1969","title":"Dolutegravir and rat whole embryo culture","year":2021,"lang":"en","type":"letter","venue":"Birth Defects Research","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institutes of Health; National Centre for the Replacement, Refinement and Reduction of Animals in Research","keywords":"Dolutegravir; Pregnancy; Fetus; Teratology; Products of conception; Dosing; Medicine; Embryo culture; Microphthalmia; Embryo; Gestation; Regimen; Andrology; Obstetrics; Surgery; Physiology; Gynecology; Internal medicine; Human immunodeficiency virus (HIV); Biology; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0006070403,0.0003299859,0.0005949471,0.0003465202,0.0002507162,0.0002320448,0.0002371732,0.001185705,0.000177985],"category_scores_gemma":[0.002594867,0.0002537236,0.0001658641,0.000634464,0.0002993237,0.00005731118,0.0004581821,0.005766679,0.00037701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001037288,"about_ca_system_score_gemma":0.0004813183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002321461,"about_ca_topic_score_gemma":0.00003125086,"domain_scores_codex":[0.9961102,0.000463526,0.0002285743,0.0007685509,0.001469698,0.0009594311],"domain_scores_gemma":[0.9973865,0.0009277908,0.00004871114,0.0007757791,0.0005190427,0.0003421794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005254758,0.00003853096,0.0008333951,0.001227048,0.00007177908,0.008951609,0.00009289537,2.394565e-7,0.0008547029,0.00003744849,0.9848793,0.002960532],"study_design_scores_gemma":[0.0008854023,0.0004377152,0.002209448,0.001277637,0.00006321597,0.0004055055,0.00006188063,0.00001566429,0.0006716907,0.0001655028,0.9935395,0.0002668966],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01934171,0.07386735,0.00005936001,0.8417687,0.000805378,0.002176439,0.000459867,0.0003797891,0.06114142],"genre_scores_gemma":[0.01652668,0.007649731,0.001542268,0.5756058,0.01371823,0.0002420212,0.004719393,0.0003091763,0.3796868],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.3185453,"threshold_uncertainty_score":0.9999915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07005679704458562,"score_gpt":0.3579688184291139,"score_spread":0.2879120213845283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}