{"id":"W3216703541","doi":"10.22203/ecm.v042a25","title":"TWIST1 controls cellular senescence and energy metabolism in mesenchymal stem cells","year":2021,"lang":"en","type":"article","venue":"European Cells and Materials","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Delta; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Arthritis Society; Dutch Arthritis Society","keywords":"Senescence; Mesenchymal stem cell; Cell biology; Gene silencing; Biology; Stem cell; Cell; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001783505,0.0002523296,0.000197781,0.0002737702,0.000163559,0.0003295744,0.00008005647,0.0001699816,0.001022864],"category_scores_gemma":[0.0001345023,0.0001189076,0.0002272296,0.0001709548,0.000222788,0.0002389672,0.0002271558,0.0002767649,0.0002606754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002488113,"about_ca_system_score_gemma":0.0001796376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002923741,"about_ca_topic_score_gemma":0.0004272179,"domain_scores_codex":[0.9998761,0.00002744778,0.00001384089,0.00002685807,0.00002481403,0.00003086416],"domain_scores_gemma":[0.9999006,0.00001684049,0.00003606916,0.000008809051,0.00001058504,0.00002704301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001095851,0.000006266594,0.0002888857,0.0000223831,0.000001797628,0.00001745669,0.00001489953,0.00005199047,0.9986566,0.00006361324,0.00001096893,0.0007554144],"study_design_scores_gemma":[0.00000684775,0.000172809,0.008575679,0.00000604381,0.00001008983,0.000107402,0.00004847743,0.0006960185,0.9886191,0.00006403012,0.001687319,0.00000612404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940494,0.001989566,0.002468784,0.00004395651,0.00002835181,0.00001499741,0.0003490985,0.00004636299,0.001009465],"genre_scores_gemma":[0.9965039,0.0008145577,0.000853149,0.00002095705,0.000005903658,0.00001751052,0.0003068979,0.0000150449,0.001462055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001022864,"threshold_uncertainty_score":0.003421843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01894853740077171,"score_gpt":0.2360789375204271,"score_spread":0.2171304001196554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}