{"id":"W3216703541","doi":"10.22203/ecm.v042a25","title":"TWIST1 controls cellular senescence and energy metabolism in mesenchymal stem cells","year":2021,"lang":"en","type":"article","venue":"European Cells and Materials","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Delta; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Arthritis Society; Dutch Arthritis Society","keywords":"Senescence; Mesenchymal stem cell; Cell biology; Gene silencing; Biology; Stem cell; Cell; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001103971,0.0002699508,0.0006659513,0.0001085102,0.00007279139,0.0001827825,0.0001085294,0.00007808429,0.0005315204],"category_scores_gemma":[0.00003075851,0.0002297863,0.00005008936,0.0001663039,0.0001275803,0.00008697814,0.0003030603,0.0001368618,0.00009082226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002207347,"about_ca_system_score_gemma":0.00007985987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001313109,"about_ca_topic_score_gemma":0.000009920136,"domain_scores_codex":[0.9971207,0.0008719544,0.0005296359,0.0006165424,0.0003515766,0.0005096146],"domain_scores_gemma":[0.9989348,0.0001181288,0.0001013295,0.0003855517,0.0001102289,0.0003499507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001208865,0.00007563268,0.00009913673,0.0002618812,0.00002759891,0.002652093,0.0001920459,7.369342e-7,0.9928577,0.0006602436,0.0003577996,0.002694271],"study_design_scores_gemma":[0.001670626,0.00007664997,0.002152561,0.0001332453,0.00004501345,0.00009595993,0.0001283016,0.00002136549,0.9141474,0.00002208068,0.08129589,0.0002109343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810694,0.004517509,0.0001680372,0.0002578435,0.0005221558,0.0002338661,0.00004505652,0.00003947574,0.01314661],"genre_scores_gemma":[0.9798672,0.003030525,0.0003658473,0.0003696563,0.0003186361,0.000007918385,0.00001723452,0.00006021341,0.01596279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08093809,"threshold_uncertainty_score":0.9370412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01894853740077171,"score_gpt":0.2360789375204271,"score_spread":0.2171304001196554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}