{"id":"W3216716877","doi":"10.1021/acsinfecdis.1c00522","title":"Exploration of BAY 11-7082 as a Potential Antibiotic","year":2021,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ontario Research Foundation","keywords":"Staphylococcus aureus; Pseudomonas aeruginosa; Inflammasome; Antibiotics; Microbiology; Biofilm; Pyrin domain; Antibacterial activity; Methicillin-resistant Staphylococcus aureus; Antibiotic resistance; Antimicrobial; Penicillin; Pathogen; Biology; Chemistry; Bacteria; Inflammation; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003162206,0.0001237342,0.0002183025,0.00006267931,0.000155338,0.00002420886,0.00006648497,0.000105991,0.0005967665],"category_scores_gemma":[0.0001168147,0.000120374,0.0001284293,0.0001273691,0.0001785992,0.000284179,0.0000738422,0.00008530646,0.0002534103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001723703,"about_ca_system_score_gemma":0.0001146563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001686722,"about_ca_topic_score_gemma":0.00008347061,"domain_scores_codex":[0.9992921,0.0001002877,0.0001849496,0.0002042351,0.00002996044,0.0001884211],"domain_scores_gemma":[0.999512,0.00005570803,0.0001020799,0.0001920661,0.0001183387,0.00001983502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007856152,0.000966423,0.04393124,0.0001070151,0.0003123677,0.00006240239,0.0002534383,0.0001633488,0.9374889,0.005978703,0.006744551,0.00391303],"study_design_scores_gemma":[0.001541555,0.0002899258,0.02489351,0.0001117877,0.0003180337,0.0002572282,0.001110134,0.000002691605,0.9620754,0.003300637,0.005733676,0.0003654034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953252,0.001380247,0.00041303,0.0001400976,0.0006912446,0.00009281753,0.00007950698,0.00009321569,0.001784654],"genre_scores_gemma":[0.9972257,0.0002671661,0.00001033993,0.0001924378,0.00006115303,0.000003307184,0.0002098687,0.00001404693,0.002015967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0245865,"threshold_uncertainty_score":0.6534174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00935653933573679,"score_gpt":0.2320952505499768,"score_spread":0.22273871121424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}