{"id":"W3216716877","doi":"10.1021/acsinfecdis.1c00522","title":"Exploration of BAY 11-7082 as a Potential Antibiotic","year":2021,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ontario Research Foundation","keywords":"Staphylococcus aureus; Pseudomonas aeruginosa; Inflammasome; Antibiotics; Microbiology; Biofilm; Pyrin domain; Antibacterial activity; Methicillin-resistant Staphylococcus aureus; Antibiotic resistance; Antimicrobial; Penicillin; Pathogen; Biology; Chemistry; Bacteria; Inflammation; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001403435,0.0003272771,0.0002664349,0.00022026,0.00009610296,0.0003598153,0.0002148222,0.0003455178,0.001101091],"category_scores_gemma":[0.00009853733,0.00009350547,0.0001669668,0.0002141835,0.0001422641,0.0002375807,0.0001728832,0.0004619378,0.0004113774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001777738,"about_ca_system_score_gemma":0.0002305272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003685877,"about_ca_topic_score_gemma":0.0005282162,"domain_scores_codex":[0.9999431,0.00001208948,0.000003467279,0.00001030661,0.00001303314,0.0000180049],"domain_scores_gemma":[0.999952,0.000007735104,0.00001028887,0.000004510977,0.000008062928,0.00001737782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003086381,0.0002184704,0.0002540437,0.0001217665,0.000007820205,0.0001924222,0.00001563742,0.0005285217,0.9875881,0.0003140179,0.0001312276,0.01031935],"study_design_scores_gemma":[0.000273884,0.0123242,0.004334043,0.00004086033,0.00008572042,0.0009194724,0.00005126143,0.002695207,0.9607443,0.0002716559,0.01823861,0.00002087039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821709,0.008097274,0.003238315,0.000410581,0.00005902544,0.0001111821,0.0003746049,0.0001162513,0.005421777],"genre_scores_gemma":[0.9863049,0.004934097,0.004726411,0.0001720489,0.00002216925,0.00004361272,0.0004443278,0.00001055109,0.003341761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001101091,"threshold_uncertainty_score":0.003683448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00935653933573679,"score_gpt":0.2320952505499768,"score_spread":0.22273871121424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}