{"id":"W3216743329","doi":"10.1139/cjpp-2021-0500","title":"Irisin relaxes rat thoracic aorta: MEK1/2 signaling pathway, K<sub>V</sub> channels, SK<sub>Ca</sub> channels, and BK<sub>Ca</sub> channels are involved in irisin-induced vasodilation","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Türkiye Bilimsel ve Teknolojik Araştırma Kurumu","keywords":"Apamin; Iberiotoxin; Endocrinology; Contraction (grammar); Internal medicine; Thoracic aorta; Potassium channel; Vasodilation; Chemistry; Potassium channel blocker; Phenylephrine; Channel blocker; Acetylcholine; Tetraethylammonium; Aorta; Calcium-activated potassium channel; Charybdotoxin; Electrical impedance myography; Calcium; Medicine; Potassium","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000118532,0.0004399375,0.0003577779,0.0001571915,0.0001680792,0.0001881902,0.00008962087,0.0002087378,0.002294418],"category_scores_gemma":[0.0001114741,0.0001597531,0.0003351207,0.0001186811,0.0001875803,0.0003209705,0.0001505571,0.0007976507,0.0002787019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001619832,"about_ca_system_score_gemma":0.0001705881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003864769,"about_ca_topic_score_gemma":0.0008100916,"domain_scores_codex":[0.9999372,0.000009148182,0.000006622224,0.00001482893,0.000009721552,0.00002235327],"domain_scores_gemma":[0.9999212,0.00001022016,0.00002734482,0.000007549279,0.000007846669,0.00002582244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005652326,0.00003714106,0.0001941269,0.00007422509,0.000006785412,0.00004724594,0.00001507038,0.00002637499,0.9981443,0.00002569273,0.00002574117,0.000838207],"study_design_scores_gemma":[0.00006489224,0.001229512,0.02547604,0.00001455945,0.00005973661,0.000299867,0.00008115521,0.0007897165,0.9703427,0.00004432716,0.001590131,0.000007401796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958417,0.002105098,0.0008965177,0.0001540752,0.00003602285,0.00001222879,0.0001642524,0.00003805287,0.0007520387],"genre_scores_gemma":[0.9927179,0.002506842,0.001557174,0.0001386149,0.00004895229,0.00002662813,0.000422727,0.00001546704,0.002565723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002294418,"threshold_uncertainty_score":0.007675588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03005891522287109,"score_gpt":0.2880680073772429,"score_spread":0.2580090921543718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}