{"id":"W3216754191","doi":"10.1182/blood-2021-148143","title":"Sirtuin 3 Inhibition Targets AML Stem Cells through Perturbation of Fatty Acid Oxidation","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Sirtuin; SIRT3; Stem cell; Cancer research; Biology; Oxidative phosphorylation; Myeloid; NAD+ kinase; Cancer cell; Cancer stem cell; Viability assay; Cancer; Biochemistry; Cell; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001584747,0.00029593,0.0003640656,0.0003303215,0.0001859938,0.0004150894,0.0002488574,0.0003018211,0.0026484],"category_scores_gemma":[0.0001572429,0.0001337043,0.0005090541,0.0002166486,0.0003017258,0.0001761679,0.0002301389,0.0009023318,0.0007341289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004290612,"about_ca_system_score_gemma":0.0003721394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009704313,"about_ca_topic_score_gemma":0.002069299,"domain_scores_codex":[0.9998529,0.00001320873,0.00001150993,0.00002383712,0.00005835455,0.00004002816],"domain_scores_gemma":[0.9999331,0.000009933722,0.00001792285,0.000007345443,0.00001300417,0.00001873633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006184349,0.0001308945,0.000787581,0.0001390212,0.00003663869,0.00007447865,0.00003974044,0.0002811943,0.9865654,0.0003395886,0.0008982346,0.01008874],"study_design_scores_gemma":[0.0001574581,0.0009312188,0.00537431,0.00001879593,0.00009120617,0.0002593652,0.00007869267,0.001720599,0.9772173,0.0002694709,0.01387161,0.000009987062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754073,0.0067777,0.006162973,0.0008493656,0.0003473187,0.0001448577,0.001715919,0.0008473971,0.007747259],"genre_scores_gemma":[0.9929278,0.00166519,0.001708356,0.0003231448,0.0000193725,0.00005022678,0.0009249173,0.00003619659,0.002344772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0026484,"threshold_uncertainty_score":0.008859813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01316622342915045,"score_gpt":0.2494064856689437,"score_spread":0.2362402622397933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}