{"id":"W3216761040","doi":"10.1016/j.jid.2021.07.190","title":"A Randomized Open-Label Clinical Trial of Lipid-Lowering Therapy in Psoriasis to Reduce Vascular Endothelial Inflammation","year":2021,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; York University; American Society of Pediatric Hematology/Oncology; Novartis; National Heart, Lung, and Blood Institute; Pfizer; National Psoriasis Foundation; Rheumatology Research Foundation; Dermatology Foundation; Institut National de la Santé et de la Recherche Médicale; American Society of Hematology; American Heart Association","keywords":"Psoriasis; Medicine; Inflammasome; Inflammation; Proinflammatory cytokine; Systemic inflammation; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002658886,0.002661409,0.005889751,0.0008353124,0.0008760322,0.001819342,0.001526789,0.003488858,0.01546551],"category_scores_gemma":[0.002826075,0.00129004,0.002674065,0.0007025673,0.002695872,0.002237725,0.0008463665,0.004899357,0.002367843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001011803,"about_ca_system_score_gemma":0.001566326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00161434,"about_ca_topic_score_gemma":0.002440108,"domain_scores_codex":[0.9986129,0.0006758147,0.00009231264,0.0002749097,0.00009224038,0.000251855],"domain_scores_gemma":[0.9980981,0.0006091509,0.0003000987,0.0002466996,0.000143322,0.0006026773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9922711,0.004240651,0.0000804847,0.0001262075,0.0002367929,0.00001145727,0.00001264441,0.00006176269,0.0006429498,0.00003980829,0.0001700932,0.002106095],"study_design_scores_gemma":[0.9852827,0.01411087,0.0002172645,0.000006546658,0.000103062,0.000004968049,0.000006129119,0.0000652713,0.00005812468,0.00004753957,0.00009314155,0.000004431613],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750879,0.003780842,0.00152025,0.00191828,0.001928736,0.009546611,0.001858052,0.000268644,0.00409072],"genre_scores_gemma":[0.9718616,0.002510173,0.003334925,0.002881957,0.001477538,0.01016698,0.001857055,0.00006802367,0.005841881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01546551,"threshold_uncertainty_score":0.05173737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08824396700725706,"score_gpt":0.3519136247551212,"score_spread":0.2636696577478641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}