{"id":"W3216778464","doi":"10.1038/s41531-021-00241-3","title":"Glucosylceramide in cerebrospinal fluid of patients with GBA-associated and idiopathic Parkinson’s disease enrolled in PPMI","year":2021,"lang":"en","type":"article","venue":"npj Parkinson s Disease","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Avid Radiopharmaceuticals; Sanofi Genzyme; Genentech; Allergan; National Institutes of Health; H. Lundbeck A/S; Servier; Voyager Therapeutics; Neurocrine Biosciences; Denali Therapeutics; Biogen; Celgene; National Institute of Neurological Disorders and Stroke; Verily Life Sciences; Teva Pharmaceutical Industries; Sanofi; GlaxoSmithKline; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; Michael J. Fox Foundation for Parkinson's Research","keywords":"Lactosylceramide; Ceramide; Internal medicine; Sphingolipid; Biomarker; Glucocerebrosidase; Medicine; Gastroenterology; Endocrinology; Chemistry; Immunology; Disease; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004039116,0.0003659395,0.0008250231,0.0003797687,0.00007713009,0.00004752344,0.0001677981,0.0001362344,0.0002008934],"category_scores_gemma":[0.001710207,0.0003350743,0.0001525138,0.001158293,0.0002069989,0.0001955263,0.0001624002,0.000437893,0.00001357695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004070591,"about_ca_system_score_gemma":0.00115762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002655838,"about_ca_topic_score_gemma":0.0005735826,"domain_scores_codex":[0.9961679,0.0004326477,0.0006657147,0.0008316966,0.001197602,0.0007044571],"domain_scores_gemma":[0.9977068,0.00009677246,0.0001755461,0.0005856256,0.0004056538,0.001029552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01095388,0.003307662,0.9806685,0.0005427749,0.00007531365,0.001805777,0.0002174512,0.00003776416,0.000259506,0.00002853631,0.00007299628,0.002029829],"study_design_scores_gemma":[0.01613129,0.0003310944,0.9795997,0.0008251835,0.0001392008,0.00000192625,0.0001377229,0.0007912978,0.0001591374,0.0001079734,0.00144483,0.0003306849],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902439,0.007653269,0.000007397759,0.0005151388,0.0000554601,0.001053633,0.0001762395,0.00004287131,0.0002520764],"genre_scores_gemma":[0.9984252,0.0005198331,0.00005205254,0.0003254824,0.00003351965,0.0001574768,0.0002721283,0.0000661014,0.0001482375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008181254,"threshold_uncertainty_score":0.9999101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01091129736818684,"score_gpt":0.2532930509242955,"score_spread":0.2423817535561087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}