{"id":"W3216820798","doi":"10.1161/circ.144.suppl_1.10659","title":"Abstract 10659: Blood DNA Methylation at TXNIP and Glycemic Changes in Response to Weight-Loss Diet Interventions: The POUNDS Lost Trial","year":2021,"lang":"en","type":"article","venue":"Circulation","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"TXNIP; Medicine; Weight loss; dNaM; Glycemic; Internal medicine; Prediabetes; Endocrinology; DNA methylation; Overweight; Glucose homeostasis; Type 2 diabetes; Insulin resistance; Methylation; Diabetes mellitus; Obesity; Biology; Genetics; Oxidative stress","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001627509,0.0007836781,0.001742452,0.0002402712,0.0003976467,0.0009640855,0.0004678953,0.001176065,0.004585696],"category_scores_gemma":[0.001315098,0.0003138563,0.001398565,0.0003334434,0.0005749412,0.0007093009,0.0004876112,0.001906762,0.0005044833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003747126,"about_ca_system_score_gemma":0.0004478453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005934451,"about_ca_topic_score_gemma":0.0006290606,"domain_scores_codex":[0.9994025,0.0003225867,0.00004996171,0.0001097389,0.000057457,0.00005776225],"domain_scores_gemma":[0.9995133,0.000103451,0.0001435407,0.00005313682,0.00003867084,0.0001478069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9557657,0.004375475,0.009343321,0.001023986,0.003509897,0.0000511521,0.00006618778,0.0002373793,0.002918102,0.0001387404,0.001317533,0.02125248],"study_design_scores_gemma":[0.811712,0.1206851,0.05636132,0.0003437716,0.005273097,0.00008945084,0.00009951041,0.0009683936,0.001188775,0.0007620838,0.002481051,0.0000354474],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894485,0.005036758,0.0005167398,0.001024657,0.0003318027,0.0008950133,0.001119397,0.00005150913,0.001575621],"genre_scores_gemma":[0.9921964,0.001056714,0.0006719441,0.00118973,0.0002683589,0.001595624,0.001046307,0.00001187666,0.001963077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004585696,"threshold_uncertainty_score":0.01534063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0270483740939405,"score_gpt":0.2979864836358477,"score_spread":0.2709381095419072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}