{"id":"W3216821319","doi":"10.1002/chem.202103839","title":"Portrait of a Family of Highly Stabilizing and Selective Guanine Quadruplex Platinum(II)‐Based Binders","year":2021,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Guanine; Platinum; Combinatorial chemistry; Chemistry; G-quadruplex; Pyridine; Nucleic acid; Derivatization; Peptide nucleic acid; Duplex (building); DNA; Selectivity; Imine; Computational biology; Stereochemistry; Biochemistry; Organic chemistry; Biology; Nucleotide; Gene; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008198489,0.0002181387,0.0001618208,0.0004092462,0.0001416039,0.0003019114,0.0002563591,0.000254107,0.001160385],"category_scores_gemma":[0.0001064631,0.0001282201,0.0001064275,0.0001981899,0.0002261019,0.0002641152,0.0001630906,0.0004402727,0.0004150613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002508725,"about_ca_system_score_gemma":0.0001226082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002416697,"about_ca_topic_score_gemma":0.0003062066,"domain_scores_codex":[0.9999493,0.000006718833,0.000002656756,0.00001515465,0.00001911597,0.000007060656],"domain_scores_gemma":[0.9999619,0.000006906128,0.000009881284,0.000005053204,0.000004806242,0.00001152966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006484462,0.00002952599,0.0004864987,0.0001061157,0.000007847102,0.0002825409,0.00007894303,0.001127614,0.9677971,0.002683495,0.0003439919,0.02699139],"study_design_scores_gemma":[0.00001384349,0.0005015455,0.002961742,0.00002489235,0.00002353405,0.003560169,0.00005933954,0.003760252,0.9198511,0.001478939,0.06774467,0.00001994629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8293016,0.0430183,0.07879306,0.001296405,0.00006812948,0.0001522648,0.001039712,0.001166925,0.04516356],"genre_scores_gemma":[0.9426202,0.01398635,0.02940312,0.0003412484,0.00003440556,0.00006166055,0.0007296789,0.00006918324,0.01275418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001160385,"threshold_uncertainty_score":0.003881872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01468597169171342,"score_gpt":0.2508727318313019,"score_spread":0.2361867601395884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}