{"id":"W3216836112","doi":"10.3390/cells10123286","title":"Neuronal Menin Overexpression Rescues Learning and Memory Phenotype in CA1-Specific α7 nAChRs KD Mice","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"MEN1; Neuroscience; Hippocampal formation; Gene knockdown; Cholinergic; Downregulation and upregulation; Biology; Nicotinic agonist; Cell biology; Receptor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001790911,0.0006946275,0.0004584298,0.000747761,0.00027659,0.0003985991,0.0004721797,0.0005081241,0.002444393],"category_scores_gemma":[0.0001073835,0.0002540646,0.0003315529,0.0001594076,0.0005256728,0.0003012616,0.000302543,0.0009763936,0.0007649543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003880657,"about_ca_system_score_gemma":0.0002418793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009312136,"about_ca_topic_score_gemma":0.002198392,"domain_scores_codex":[0.9997938,0.00001711653,0.00002855254,0.00006508605,0.00005682062,0.00003849089],"domain_scores_gemma":[0.9996758,0.00002883786,0.0001193663,0.00002384599,0.00002555388,0.0001266164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005400479,0.0000177024,0.00008701518,0.00001540789,0.00000419132,0.00007360442,0.00001601916,0.00003301332,0.99923,0.00005947398,0.00001421516,0.0003954483],"study_design_scores_gemma":[0.00001556328,0.0001803584,0.0035737,0.000008948448,0.00001961665,0.0002652935,0.00005499984,0.0004972529,0.9941888,0.00007701889,0.001113108,0.000005325562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932942,0.000672781,0.003469674,0.0001516946,0.00005600408,0.00002573912,0.0006759619,0.0002240742,0.001429767],"genre_scores_gemma":[0.9764807,0.001089335,0.003901769,0.00009314177,0.00002153685,0.000054253,0.0008942578,0.0001750948,0.01729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002444393,"threshold_uncertainty_score":0.00817728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007282499243104174,"score_gpt":0.2393522646049197,"score_spread":0.2320697653618156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}