{"id":"W3216838449","doi":"10.3389/fmicb.2021.737031","title":"Foot-and-Mouth Disease Virus 3C Protease Antagonizes Interferon Signaling and C142T Substitution Attenuates the FMD Virus","year":2021,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Animal Disease Management and Epidemiology","field":"Agricultural and Biological Sciences","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Research Foundation of Korea; Korea Research Institute of Bioscience and Biotechnology; National Research Foundation; McGill University","keywords":"Protease; Biology; Interferon; Virus; Virology; Foot-and-mouth disease virus; RIG-I; Viral replication; Aphthovirus; Microbiology; Enzyme; RNA; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001761611,0.0004552252,0.0002898744,0.0001871601,0.0001526651,0.0002550514,0.0002874531,0.0004856969,0.001427966],"category_scores_gemma":[0.0001331206,0.0001441488,0.0004530011,0.0001194159,0.0003212239,0.000183461,0.0001511138,0.0006446805,0.0003524673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003226456,"about_ca_system_score_gemma":0.0002598438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009635721,"about_ca_topic_score_gemma":0.0008632302,"domain_scores_codex":[0.9997868,0.00004271703,0.00003432548,0.0000344021,0.00004802773,0.0000537941],"domain_scores_gemma":[0.9998569,0.00002379339,0.00005015389,0.00001421638,0.00001266973,0.00004217428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003330408,0.00010416,0.0001458659,0.00002579675,0.000007975949,0.000104473,0.00000817343,0.00006366539,0.9986664,0.00007499778,0.00003565092,0.0004298574],"study_design_scores_gemma":[0.00008115243,0.001026652,0.004194065,0.000009435494,0.00003125779,0.000511427,0.00002516842,0.00162766,0.9906594,0.00003701198,0.001787339,0.00000946723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981743,0.0003170056,0.0005765631,0.00006918635,0.00003442184,0.00002762158,0.0002330174,0.00002349399,0.0005443745],"genre_scores_gemma":[0.9968167,0.000241809,0.000950886,0.00006725566,0.00001421188,0.0000331823,0.0004763823,0.00002063313,0.001378941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001427966,"threshold_uncertainty_score":0.004777074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01704163808825436,"score_gpt":0.2182925896122772,"score_spread":0.2012509515240229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}