{"id":"W3216839499","doi":"10.21203/rs.3.rs-1009236/v1","title":"Development and Evaluation of a Novel Fast Broad-Range ITS/LSU DNA PCR and Sequencing Assay (FBR-PCR/S) for Rapid Diagnosis of Invasive Fungal Diseases: Multi-Year Experience in a Large Canadian Healthcare Zone and a Literature Review","year":2021,"lang":"en","type":"review","venue":"Research Square","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; University of Calgary","funders":"Alberta Precision Laboratories; Calgary Laboratory Services","keywords":"Biology; Polymerase chain reaction; DNA extraction; Real-time polymerase chain reaction; Aspergillus; Internal medicine; Microbiology; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003744068,0.0006547834,0.0007028372,0.003862997,0.0007247978,0.001725643,0.001112276,0.0006927968,0.0005688358],"category_scores_gemma":[0.004409241,0.0002809113,0.0004844993,0.003911222,0.0009143528,0.0006838314,0.000377473,0.0003508369,0.0002092501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004889172,"about_ca_system_score_gemma":0.01462549,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.3723673,"about_ca_topic_score_gemma":0.5079955,"domain_scores_codex":[0.9979517,0.0002785523,0.0003291552,0.0002607172,0.00101237,0.0001675202],"domain_scores_gemma":[0.9957246,0.0008593948,0.0005817036,0.00008245387,0.002576591,0.0001752283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003556345,0.000174824,0.139495,0.01761725,0.0003823728,0.005151831,0.002299409,0.0009636009,0.031771,0.0004259488,0.003942502,0.7974205],"study_design_scores_gemma":[0.000151238,0.002223151,0.6373115,0.01342162,0.004386326,0.04289478,0.0131836,0.005062543,0.05092195,0.000548999,0.2294777,0.0004166201],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2040064,0.7795872,0.006067176,0.001884362,0.0002635428,0.0004312622,0.0007566018,0.0001022673,0.00690109],"genre_scores_gemma":[0.4959559,0.4760639,0.02326591,0.001299224,0.0002296941,0.0001256874,0.001365861,0.00003577032,0.001658059],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6276327,"threshold_uncertainty_score":0.7403997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2514657906016542,"score_gpt":0.4741807608999696,"score_spread":0.2227149702983154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}