{"id":"W3216848432","doi":"10.1038/s41419-021-04402-3","title":"Misoprostol treatment prevents hypoxia-induced cardiac dysfunction through a 14-3-3 and PKA regulatory motif on Bnip3","year":2021,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; St. Boniface Hospital; Research Institute in Oncology and Hematology; University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada; Heart and Stroke Foundation of Canada","keywords":"Hypoxia (environmental); Phosphorylation; Cell biology; Homeostasis; Misoprostol; Biology; Programmed cell death; Mitochondrion; Pharmacology; Endocrinology; Internal medicine; Chemistry; Medicine; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003426285,0.0001748584,0.0001515436,0.00001840075,0.000116438,0.00002463911,0.00002763494,0.0001233646,0.00003890219],"category_scores_gemma":[0.00005282104,0.0001567695,0.00009465541,0.00003515272,0.00003070163,0.000005020953,0.00003944525,0.00004596735,0.00001315594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001539033,"about_ca_system_score_gemma":0.0001188455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001065771,"about_ca_topic_score_gemma":0.000002972243,"domain_scores_codex":[0.9990389,0.00009642528,0.0001190768,0.0004902979,0.00007983753,0.0001754197],"domain_scores_gemma":[0.9992667,0.00001076316,0.00003878702,0.0003251603,0.00003878137,0.0003197873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0011993,0.0005477696,0.01291094,0.00009806329,0.00009397242,0.00008785029,0.0001248179,0.00001601348,0.9705061,0.0004758423,0.004755367,0.009183913],"study_design_scores_gemma":[0.007535052,0.002718619,0.07811879,0.00005922305,0.0005982445,0.00005003171,0.0002379552,0.00006254949,0.6114667,0.00166374,0.2965266,0.0009624508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991509,0.004154203,0.0001005542,0.0001006708,0.0007184898,0.0002438337,0.00005238809,0.00001465074,0.003106257],"genre_scores_gemma":[0.9883805,0.001100737,0.0001606382,0.0006667834,0.0004259406,0.00005477192,0.0003606537,0.00001940823,0.008830551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3590395,"threshold_uncertainty_score":0.6392875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01577728516983748,"score_gpt":0.2357830028982875,"score_spread":0.22000571772845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}