{"id":"W3216894132","doi":"10.1093/neuonc/noab196.081","title":"STEM-05. FUNCTIONAL MAPPING REVEALS WIDESPREAD REMODELLING AND UNRECOGNIZED PATHWAY DEPENDENCIES IN RECURRENT GLIOBLASTOMA","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; University Health Network; University of Toronto; McMaster University","funders":"","keywords":"PTEN; Cancer research; Biology; Signal transduction; Synthetic lethality; Genetics; PI3K/AKT/mTOR pathway; DNA repair; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009985839,0.0001983687,0.0001870804,0.0003497127,0.0001216806,0.0003384416,0.0001781471,0.0001892928,0.001886532],"category_scores_gemma":[0.00009186958,0.0001252844,0.0001552766,0.0002116188,0.0001731544,0.00008538989,0.0001648577,0.0002448423,0.0003547132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002846354,"about_ca_system_score_gemma":0.0001896056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001143564,"about_ca_topic_score_gemma":0.001763405,"domain_scores_codex":[0.9999113,0.000005940863,0.000006955037,0.00002233888,0.0000353278,0.000018213],"domain_scores_gemma":[0.9999284,0.000009381186,0.00002704247,0.000009064384,0.000007423252,0.00001871142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005178482,0.00001040904,0.0006904863,0.00001900444,0.000005602358,0.00007268367,0.00001262975,0.0001138777,0.9968117,0.0001411778,0.00005483878,0.002015749],"study_design_scores_gemma":[0.00001303305,0.0001997142,0.02619061,0.000004805376,0.00003165252,0.0008409604,0.0000416066,0.003005237,0.9655191,0.0001820669,0.003965773,0.000005369724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939837,0.0002832927,0.003358989,0.00005811627,0.000008114122,0.00001637186,0.001035691,0.0002400203,0.001015864],"genre_scores_gemma":[0.9944894,0.0001653714,0.002001524,0.00003042552,0.000001946219,0.00001754621,0.00121532,0.00003080126,0.002047805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001886532,"threshold_uncertainty_score":0.006311119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04605082114340747,"score_gpt":0.2971969502306166,"score_spread":0.2511461290872091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}