{"id":"W3216894132","doi":"10.1093/neuonc/noab196.081","title":"STEM-05. FUNCTIONAL MAPPING REVEALS WIDESPREAD REMODELLING AND UNRECOGNIZED PATHWAY DEPENDENCIES IN RECURRENT GLIOBLASTOMA","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; University Health Network; University of Toronto; McMaster University","funders":"","keywords":"PTEN; Cancer research; Biology; Signal transduction; Synthetic lethality; Genetics; PI3K/AKT/mTOR pathway; DNA repair; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003887911,0.000179778,0.0002898824,0.0001040231,0.0001034831,0.00003050898,0.0001199442,0.0002588097,0.00006038534],"category_scores_gemma":[0.0003241025,0.0001677786,0.00008074044,0.0001955155,0.00009834945,0.000009516498,0.0002843147,0.0003082586,0.00001691239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005714306,"about_ca_system_score_gemma":0.0004326562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000956916,"about_ca_topic_score_gemma":0.0002468001,"domain_scores_codex":[0.9979957,0.0004358888,0.0003480726,0.0006235296,0.0001922967,0.0004045322],"domain_scores_gemma":[0.9990815,0.0002754831,0.00009174368,0.0002606891,0.0001555942,0.0001350207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004105266,0.0001057848,0.001125089,0.00003312747,0.00002392412,0.0003664733,0.00006668497,0.0000708199,0.9275089,0.00003573332,0.0009295499,0.06932337],"study_design_scores_gemma":[0.001823125,0.001249515,0.0005086244,0.00007310027,0.00001408059,0.0003925719,0.0006095545,0.0009570761,0.82863,0.0002613409,0.1651751,0.0003059566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994257,0.001850961,0.001514846,0.0007450985,0.0004298779,0.0001964193,0.00002337186,0.0000164088,0.0009660332],"genre_scores_gemma":[0.9961894,0.001525742,0.000709147,0.0006975376,0.0002699124,0.00004820476,0.00006444172,0.00002924698,0.0004663328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1642456,"threshold_uncertainty_score":0.6841813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04605082114340747,"score_gpt":0.2971969502306166,"score_spread":0.2511461290872091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}